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Orioles vs Cardinals Prediction and MLB Tips - 28 May 2025

The Baltimore Orioles will sqaure off with the St. Louis Cardinals in MLB action at Oriole Park at Camden Yards on Wednesday, starting at 8:35am AEST.

Tomoyuki Sugano (4-3, 3.07 ERA) will be on the bump for the Orioles, up against Andre Pallante (4-3, 4.18 ERA) for the Cardinals.

This article features Stats Insider's best betting tips for the Orioles vs Cardinals game, as well as the latest betting odds in Australia.

Who Will Win?

Using trusted machine learning and data, Stats Insider has simulated the result of Wednesday's Baltimore vs St. Louis MLB match-up 10,000 times.

Our independent predictive analytics model gives the Cardinals a 51% chance of beating the Orioles at Oriole Park at Camden Yards.

Orioles vs Cardinals: Odds

The latest betting odds in Australia for Wednesday's MLB game at Oriole Park at Camden Yards are shown below:

  • Head to Head: Orioles $2.05, Cardinals $1.80
  • Line: Orioles +1.5 ($1.61), Cardinals -1.5 ($2.40)
  • Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, the bookmakers currently have the Orioles at $2.05 and the Cardinals at $1.80.

The Orioles are listed as 1.5-run underdogs against the Cardinals, with odds of $1.61 available at TAB.

For the favourite Cardinals (-1.5) to cover the line, TAB offers odds of $2.40.

The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the Orioles (+1.5) are predicted to cover the line 61% of the time, while the 8.5-run over/under is expected to go over 51% of the time.

Orioles vs Cardinals: Betting Tips

  • Head to Head: Baltimore at $2.05 with TAB
  • Line: Orioles +1.5 at $1.61 with TAB
  • Total Runs: Over 8.5 at $1.91 with TAB

Stats Insider's Orioles vs Cardinals best bets are based on complex modelling and gambling experience to bring you the best possible advice 24/7.

While the Cardinals have a higher chance of winning the game, betting on the Orioles to win is our preferred option due to the 1.8% edge found when comparing our data-driven probabilities to the odds currently available.

Taking advantage of the edges seen on Stats Insider is one of the keys to being profitable in the long run.

Orioles vs Cardinals: Prediction

Stats Insider provides full coverage of the Baltimore vs St. Louis game on Wednesday, including data-driven predictions and the best betting tips.

Remember, our model updates frequently, so bookmark this article for the latest betting analysis before the Baltimore vs St. Louis game.

As always, see our Best Bets for the best tips on every MLB game, plus predictions for a wide range of other sports.

Orioles vs Cardinals: Essential Details

The match-up between the Orioles and Cardinals at Oriole Park at Camden Yards is scheduled to start at 8:35am AEST on Wednesday.

All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.

Conclusion

Our Baltimore vs St. Louis predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.

If you choose to use our predictions for betting purposes, it's important to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

More on MLB

Stats Insider is your go-to source for betting on the MLB in Australia, with the latest MLB betting news, tips for every MLB game, and futures probabilities for the MLB.

Stats Insider

Stats Insider, Australia's leading predictive analytics website, offers Australian sports fans innovative tools and content to enhance their enjoyment of major sporting events both domestically and internationally. Our goal is to transform the sports fan experience by providing readily accessible, data-driven content for sports enthusiasts like us.

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