Marlins vs Cardinals Prediction and MLB Tips - 22 April 2026
Last updated: Apr 21, 2026, 10:40PM | Published: Apr 20, 2026, 5:33PM
The Miami Marlins will sqaure off with the St. Louis Cardinals in MLB action at loanDepot park on Wednesday, commencing at 8:40am AEST.
The Marlins will have Chris Paddack (0-3, 5.59 ERA) start, while the Cardinals are going with Dustin May (2-2, 6.98 ERA).
This article features Stats Insider's top betting tips for the Marlins vs Cardinals game, along with the latest betting odds in Australia.
Who Will Win?
Based on trusted computer power and data, Stats Insider has simulated the result of Wednesday's Miami vs St. Louis MLB game 10,000 times.
Our independent predictive analytics model gives the Marlins a 53% chance of defeating the Cardinals at loanDepot park.
Marlins vs Cardinals: Odds
The latest betting odds in Australia for Wednesday's MLB game at loanDepot park are shown here:
- Head to Head: Marlins $1.80, Cardinals $2.05
- Line: Marlins -1.5 ($2.70), Cardinals +1.5 ($1.49)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Marlins at $1.80 and the Cardinals at $2.05.
The Marlins are listed as 1.5-run favourites against the Cardinals, with odds of $2.70 available at TAB.
For the underdog Cardinals (+1.5) to cover the line, TAB offers odds of $1.49.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 64% of the time, while the 8.5-run over/under is expected to go over 53% of the time.
Marlins vs Cardinals: Betting Tips
- Head to Head: St. Louis at $2.05 with TAB
- Line: Cardinals +1.5 at $1.49 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
Today's Marlins vs Cardinals betting tips are based on market-leading simulations and betting expertise to help you place smarter bets with your chosen online bookie.
While the Marlins have a higher chance of winning the game, betting on the Cardinals to win is our recommended option because of the edge identified when comparing our data-driven probabilities to the odds currently on offer.
Taking advantage of the edges seen here at Stats Insider is pivotal to being a profitable bettor in the long run.
Marlins vs Cardinals: Prediction
Stats Insider provides full betting coverage of the Miami vs St. Louis game on Wednesday, including data-driven predictions and expert tips.
Remember, our model updates regularly, so keep checking this page for the latest betting predictions before the Miami vs St. Louis match-up.
As always, see Stats Insider's Best Bets to get betting tips for every MLB game, plus predictions for a wide range of other sports.
Marlins vs Cardinals: Essential Details
The match-up between the Marlins and Cardinals at loanDepot park is scheduled to commence at 8:40am AEST on Wednesday.
- Teams: Miami Marlins vs St. Louis Cardinals
- Date: Wednesday 22 April 2026
- Time: 8:40am AEST
- Venue: loanDepot park
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Miami vs St. Louis predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you decide to use our MLB predictions for betting purposes, it's vital to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on MLB
Stats Insider is your go-to source for betting on the MLB in Australia, with the latest MLB betting news, predictions for every MLB game, and futures odds for the MLB.
