Mariners vs Cardinals Prediction and MLB Tips - 10 September 2025
Last updated: Sep 9, 2025, 5:09AM | Published: Sep 8, 2025, 6:31PM
The Seattle Mariners will take on the St. Louis Cardinals in MLB action at T-Mobile Park on Wednesday, starting at 11:40am AEST.
The Mariners will have George Kirby (8-7, 4.47 ERA) start, up against Matthew Liberatore (7-11, 4.15 ERA) for the Cardinals.
This article features Stats Insider's prediction and tips for the Mariners vs Cardinals game, as well as the latest betting odds in Australia.
Who Will Win?
Based on advanced computer power and data, Stats Insider has simulated the outcome of Wednesday's Seattle vs St. Louis MLB game 10,000 times.
Our independent predictive analytics model currently gives the Mariners a 65% chance of winning against the Cardinals at T-Mobile Park.
Mariners vs Cardinals: Odds
The latest betting odds in Australia for Wednesday's MLB game at T-Mobile Park are shown here:
- Head to Head: Mariners $1.42, Cardinals $2.91
- Line: Mariners -1.5 ($1.97), Cardinals +1.5 ($1.83)
- Total (Over/Under 7.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Mariners at $1.42 and the Cardinals at $2.91.
The Mariners are 1.5-run favourites against the Cardinals, with odds of $1.97 available at TAB.
For the underdog Cardinals (+1.5) to cover the line, TAB offers odds of $1.83.
The over/under for total runs scored is set at 7.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Cardinals (+1.5) are predicted to cover the line 54% of the time, while the 7.5-run over/under is expected to is considered an equal 50-50 chance of hitting.
Mariners vs Cardinals: Best Bets
- Head to Head: St. Louis at $2.91 with TAB
- Line: Cardinals +1.5 at $1.83 with TAB
- Total Runs: Over 7.5 at $1.91 with TAB
Stats Insider's Mariners vs Cardinals betting tips are based on market-leading modelling and betting expertise to provide you with the best possible advice 24/7/365.
While the Mariners have a higher chance of winning the game, betting on the Cardinals to win is our preferred option because of the 1.7% edge identified when comparing our data-led probabilities to the odds currently on offer.
Making use of the edges seen here at Stats Insider is crucial to achieving long-term profitability.
Mariners vs Cardinals: Prediction
Stats Insider provides full coverage of the Seattle vs St. Louis game on Wednesday, including data-driven predictions and the best betting tips.
Our model updates frequently, so refresh this article for the latest betting analysis before the Seattle vs St. Louis match-up.
As always, see Stats Insider's Best Bets for the best tips on every MLB game, as well as predictions for a wide range of other sports.
Mariners vs Cardinals: Essential Details
The match-up between the Mariners and Cardinals at T-Mobile Park is scheduled to begin at 11:40am AEST on Wednesday.
- Teams: Seattle Mariners vs St. Louis Cardinals
- Date: Wednesday 10 September 2025
- Time: 11:40am AEST
- Venue: T-Mobile Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Seattle vs St. Louis predictions have been made thanks to 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's important to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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