Lions vs Steelers Prediction and Preview - NFL Week 16, 2025
Last updated: Dec 14, 2025, 3:05PM | Published: Dec 14, 2025, 5:00AM
The Detroit Lions will sqaure off with the Pittsburgh Steelers in NFL Week 16 action at Ford Field on Monday, December 22, commencing at 8:25am AEDT.
This article features Stats Insider's prediction and tips for the Lions vs Steelers game, plus the latest betting odds in Australia.
Who Will Win?
Based on trusted machine learning and data, Stats Insider has simulated the outcome of Steelers vs Lions 10,000 times.
Our leading predictive analytics model currently gives the Lions a 72% chance of beating the Steelers in Week 16 of the NFL season.
Lions vs Steelers: Odds
The current Bet365 betting odds in Australia for this NFL game at Ford Field are listed below:
- Head to Head: Lions $1.33, Steelers $3.40
- Line: Lions -6.5 ($1.91), Steelers +6.5 ($1.91)
- Total (Over/Under 49.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Lions at $1.33 and the Steelers at $3.40.
The Lions are listed as 6.5-point favourites against the Steelers, with odds of $1.91 available at Bet365.
For the underdog Steelers (+6.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 49.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the bookmakers have got it right and both the Lions and the Steelers have a 50% chance of covering the line.
The 49.5-point over/under is expected to is also considered an equal 50-50 chance of hitting.
Lions vs Steelers: Best Bets
- Head to Head: Pittsburgh at $3.40 with Bet365
- Line: Steelers +6.5 at $1.91 with Bet365
- Total Points: Under 49.5 at $1.91 with Bet365
Our Lions vs Steelers best bets are based on market-leading simulations and wagering intelligence to help you place smarter bets with your chosen online bookie.
While the Lions have a higher chance of winning the game, betting on the Steelers to win is our recommended option due to the edge found when comparing our data-driven probabilities to the odds currently on offer.
Making use of the edges published on Stats Insider is pivotal to being a profitable bettor in the long run.
Lions vs Steelers: Prediction
Stats Insider's predicted final score for Lions vs Steelers at Ford Field in Week 16 is the Lions prevailing 28-21.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the Detroit vs Pittsburgh game in Week 16, including data-driven predictions and the best betting tips.
18+. Odds correct at time of publishing and subject to change.Remember, our model updates regularly, so bookmark this page for the latest betting analysis before the Detroit vs Pittsburgh match-up.
As always, see Stats Insider's Best Bets to get betting tips for every NFL game, plus predictions for a wide range of other sports.
Lions vs Steelers: Week 16 Essential Details
The NFL Week 16 game between the Lions and Steelers at Ford Field is scheduled to begin at 8:25am AEDT on Monday, December 22.
- Teams: Detroit Lions vs Pittsburgh Steelers
- Date: Monday 22 December 2025
- Time: 8:25am AEDT
- Venue: Ford Field
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our Detroit vs Pittsburgh predictions have been made based on 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's vital that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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