Guardians vs White Sox Prediction and MLB Tips - 15 September 2025
Last updated: Sep 14, 2025, 10:35AM | Published: Sep 13, 2025, 7:32PM
The Cleveland Guardians will face the Chicago White Sox in MLB action at Progressive Field on Monday, beginning at 3:40am AEST.
Slade Cecconi (6-6, 4.45 ERA) will get the ball for the Guardians, pitting him against Yoendrys Gómez (3-2, 5.05 ERA) for the White Sox.
This article features Stats Insider's top betting tips for the Guardians vs White Sox game, as well as the latest betting odds in Australia.
Who Will Win?
Using advanced computer power and data, Stats Insider has simulated the result of Monday's Cleveland vs White Sox MLB game 10,000 times.
Our independent predictive analytics model currently gives the Guardians a 57% chance of winning against the White Sox at Progressive Field.
Guardians vs White Sox: Odds
The latest betting odds in Australia for Monday's MLB game at Progressive Field are listed below:
- Head to Head: Guardians $1.59, White Sox $2.45
- Line: Guardians -1.5 ($2.25), White Sox +1.5 ($1.67)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Guardians at $1.59 and the White Sox at $2.45.
The Guardians are listed as 1.5-run favourites against the White Sox, with odds of $2.25 available at TAB.
For the underdog White Sox (+1.5) to cover the line, TAB offers odds of $1.67.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the White Sox (+1.5) are predicted to cover the line 60% of the time, while the 8.5-run over/under is expected to stay under 52% of the time.
Guardians vs White Sox: Best Bets
- Head to Head: White Sox at $2.45 with TAB
- Line: White Sox +1.5 at $1.67 with TAB
- Total Runs: Under 8.5 at $1.91 with TAB
Our Guardians vs White Sox best bets are based on world-class modelling and wagering experience to give you the best possible advice every day of the year.
While the Guardians have a higher chance of winning the game, betting on the White Sox to win is our preferred option because of the 3.2% edge identified when comparing our data-led probabilities to the odds currently on offer.
Taking advantage of the edges seen here at Stats Insider is crucial to achieving long-term profitability.
Guardians vs White Sox: Prediction
Stats Insider provides full coverage of the Cleveland vs White Sox game on Monday, including data-driven predictions and expert tips.
Remember, our model updates frequently, so bookmark this page for the latest betting analysis before the Cleveland vs White Sox match-up.
As always, see our Best Bets to get betting tips for every MLB game, as well as predictions for a wide range of other sports.
Guardians vs White Sox: Essential Details
The game between the Guardians and White Sox at Progressive Field is scheduled to start at 3:40am AEST on Monday.
- Teams: Cleveland Guardians vs Chicago White Sox
- Date: Monday 15 September 2025
- Time: 3:40am AEST
- Venue: Progressive Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cleveland vs White Sox predictions are based on 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our MLB predictions for betting purposes, it's crucial that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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