Guardians vs White Sox Prediction and MLB Tips - 15 September 2025
Last updated: Sep 14, 2025, 5:40PM | Published: Sep 13, 2025, 7:32PM
The Cleveland Guardians will take on the Chicago White Sox in MLB action at Progressive Field on Monday, commencing at 3:40am AEST.
Slade Cecconi (6-6, 4.45 ERA) will start for the Guardians, while the White Sox will counter with Yoendrys Gómez (3-2, 5.05 ERA).
This article features Stats Insider's free betting tips for the Guardians vs White Sox game, along with the latest betting odds in Australia.
Who Will Win?
Based on trusted computer power and data, Stats Insider has simulated the result of Monday's Cleveland vs White Sox MLB game 10,000 times.
Our proven predictive analytics model currently gives the Guardians a 58% chance of winning against the White Sox at Progressive Field.
Guardians vs White Sox: Odds
The latest betting odds in Australia for Monday's MLB game at Progressive Field are shown below:
- Head to Head: Guardians $1.62, White Sox $2.35
- Line: Guardians -1.5 ($2.29), White Sox +1.5 ($1.65)
- Total (Over/Under 8 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Guardians at $1.62 and the White Sox at $2.35.
The Guardians are listed as 1.5-run favourites against the White Sox, with odds of $2.29 available at TAB.
For the underdog White Sox (+1.5) to cover the line, TAB offers odds of $1.65.
The over/under for total runs scored is set at 8 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the White Sox (+1.5) are predicted to cover the line 61% of the time, while the 8-run over/under is expected to stay under 51% of the time.
Guardians vs White Sox: Betting Tips
- Head to Head: White Sox at $2.35 with TAB
- Line: White Sox +1.5 at $1.65 with TAB
- Total Runs: Over 8 at $1.91 with TAB
These Guardians vs White Sox best bets are based on world-class simulations and betting expertise to provide you with the best possible advice around the clock.
While the Guardians have a higher chance of winning the game, betting on the White Sox to win is our recommended option due to the 1.6% edge identified when comparing our data-driven probabilities to the odds currently available.
Making use of the edges seen on Stats Insider is pivotal to being a profitable bettor in the long run.
Furthermore, despite the Under being more likely to hit in this game, Over 8 is our best bet due to the better odds ($1.91) that are available from TAB.
Guardians vs White Sox: Prediction
Stats Insider provides full coverage of the Cleveland vs White Sox game on Monday, including data-driven predictions and free tips.
Remember, our model updates frequently, so keep checking this article for the latest betting predictions before the Cleveland vs White Sox game.
As always, see our Best Bets to get betting tips on every MLB game, as well as predictions for a wide range of other sports.
Guardians vs White Sox: Essential Details
The match-up between the Guardians and White Sox at Progressive Field is scheduled to begin at 3:40am AEST on Monday.
- Teams: Cleveland Guardians vs Chicago White Sox
- Date: Monday 15 September 2025
- Time: 3:40am AEST
- Venue: Progressive Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Cleveland vs White Sox predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you choose to use our MLB predictions for betting purposes, it's crucial that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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