Guardians vs Tigers Prediction and MLB Tips - 26 September 2025
Last updated: Sep 25, 2025, 10:40PM | Published: Sep 25, 2025, 2:29PM
The Cleveland Guardians will take on the Detroit Tigers in Game 1 of the American League Division Series at Progressive Field on Friday, commencing at 8:40am AEST.
The Guardians will send Parker Messick (3-0, 2.08 ERA) to the mound, pitting him against Troy Melton (3-2, 2.79 ERA) for the Tigers.
This article features Stats Insider's prediction and tips for the Guardians vs Tigers game, along with the latest betting odds in Australia.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the result of Friday's Cleveland vs Detroit MLB game 10,000 times.
Our leading predictive analytics model currently gives the Guardians a 59% chance of winning against the Tigers at Progressive Field.
Guardians vs Tigers: Odds
The current betting odds in Australia for Friday's MLB game at Progressive Field are shown here:
- Head to Head: Guardians $1.62, Tigers $2.35
- Line: Guardians -1.5 ($2.40), Tigers +1.5 ($1.61)
- Total (Over/Under 7.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Guardians at $1.62 and the Tigers at $2.35.
The Guardians are listed as 1.5-run favourites against the Tigers, with odds of $2.40 available at TAB.
For the underdog Tigers (+1.5) to cover the line, TAB offers odds of $1.61.
The over/under for total runs scored is set at 7.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Tigers (+1.5) are predicted to cover the line 60% of the time, while the 7.5-run over/under is expected to go over 55% of the time.
Guardians vs Tigers: Betting Tips
- Head to Head: Detroit at $2.35 with TAB
- Line: Tigers +1.5 at $1.61 with TAB
- Total Runs: Over 7.5 at $1.91 with TAB
Our Guardians vs Tigers predictions are based on complex modelling and gambling intelligence to give you the best possible advice 24/7/365.
While the Guardians have a higher chance of winning the game, betting on the Tigers to win is our recommended option because of the edge identified when comparing our data-led probabilities to the odds currently on offer.
Making use of the edges seen on Stats Insider is crucial to being profitable in the long run.
Guardians vs Tigers: Prediction
Stats Insider provides full betting coverage of the Cleveland vs Detroit game on Friday, including data-driven predictions and live win probabilitiestips.
Remember, our model updates regularly, so refresh this page for the latest betting tips before the Cleveland vs Detroit match-up.
As always, see Stats Insider's Best Bets to get the best tips on every MLB game, plus predictions for a wide range of other sports.
Guardians vs Tigers: Essential Details
The game between the Guardians and Tigers at Progressive Field is scheduled to start at 8:40am AEST on Friday.
- Teams: Cleveland Guardians vs Detroit Tigers
- Date: Friday 26 September 2025
- Time: 8:40am AEST
- Venue: Progressive Field
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cleveland vs Detroit predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's vital to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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