Guardians vs Tigers Prediction and MLB Tips - 25 September 2025
Last updated: Sep 24, 2025, 11:16PM | Published: Sep 23, 2025, 7:31PM
The Cleveland Guardians will take on the Detroit Tigers in Game 191 of the American League Division Series at Progressive Field on Thursday, beginning at 8:40am AEST.
The Guardians will have Tanner Bibee (11-11, 4.34 ERA) start, pitting him against Jack Flaherty (8-14, 4.60 ERA) for the Tigers.
This article features Stats Insider's prediction and tips for the Guardians vs Tigers game, plus the latest betting odds in Australia.
Who Will Win?
Utilising trusted machine learning and data, Stats Insider has simulated the outcome of Thursday's Cleveland vs Detroit MLB match-up 10,000 times.
Our leading predictive analytics model currently gives the Guardians a 56% chance of defeating the Tigers at Progressive Field.
Guardians vs Tigers: Odds
The current betting odds in Australia for Thursday's MLB game at Progressive Field are shown below:
- Head to Head: Guardians $1.67, Tigers $2.25
- Line: Guardians -1.5 ($2.50), Tigers +1.5 ($1.56)
- Total (Over/Under 7.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Guardians at $1.67 and the Tigers at $2.25.
The Guardians are 1.5-run favourites against the Tigers, with odds of $2.50 available at TAB.
For the underdog Tigers (+1.5) to cover the line, TAB offers odds of $1.56.
The over/under for total runs scored is set at 7.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Tigers (+1.5) are predicted to cover the line 63% of the time, while the 7.5-run over/under is expected to go over 57% of the time.
Guardians vs Tigers: Betting Tips
- Head to Head: Detroit at $2.25 with TAB
- Line: Tigers +1.5 at $1.56 with TAB
- Total Runs: Over 7.5 at $1.91 with TAB
Our Guardians vs Tigers predictions are based on complex simulations and wagering experience to bring you the best possible advice every time.
While the Guardians have a higher chance of winning the game, betting on the Tigers to win is our recommended option due to the 1.9% edge found when comparing our data-led probabilities to the odds currently on offer.
Making use of the edges seen on Stats Insider is one of the keys to being profitable in the long run.
Guardians vs Tigers: Prediction
Stats Insider provides full coverage of the Cleveland vs Detroit game on Thursday, including data-driven predictions and top betting tips.
Our model updates frequently, so keep checking this page for the latest betting tips before the Cleveland vs Detroit game.
As always, see our Best Bets for betting tips on every MLB game, plus predictions for a wide range of other sports.
Guardians vs Tigers: Essential Details
The game between the Guardians and Tigers at Progressive Field is scheduled to start at 8:40am AEST on Thursday.
- Teams: Cleveland Guardians vs Detroit Tigers
- Date: Thursday 25 September 2025
- Time: 8:40am AEST
- Venue: Progressive Field
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Cleveland vs Detroit predictions are based on 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you choose to use our MLB predictions for betting purposes, it's important that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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