Guardians vs Tigers Prediction and MLB Tips - 24 September 2025
Last updated: Sep 23, 2025, 10:43PM | Published: Sep 22, 2025, 4:28PM
The Cleveland Guardians will face the Detroit Tigers in Game 190 of the American League Division Series at Progressive Field on Wednesday, starting at 8:40am AEST.
The Guardians will send Gavin Williams (11-5, 3.06 ERA) to the mound, while the Tigers are going with Tarik Skubal (13-5, 2.23 ERA).
This article features Stats Insider's prediction and tips for the Guardians vs Tigers game, plus the latest betting odds in Australia.
Who Will Win?
Using advanced computer power and data, Stats Insider has simulated the result of Wednesday's Cleveland vs Detroit MLB game 10,000 times.
Our proven predictive analytics model currently gives the Tigers a 59% chance of beating the Guardians at Progressive Field.
Guardians vs Tigers: Odds
The current betting odds in Australia for Wednesday's MLB game at Progressive Field are listed below:
- Head to Head: Guardians $2.35, Tigers $1.62
- Line: Guardians +1.5 ($1.72), Tigers -1.5 ($2.20)
- Total (Over/Under 6.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Guardians at $2.35 and the Tigers at $1.62.
The Guardians are listed as 1.5-run underdogs against the Tigers, with odds of $1.72 available at TAB.
For the favourite Tigers (-1.5) to cover the line, TAB offers odds of $2.20.
The over/under for total runs scored is set at 6.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Guardians (+1.5) are predicted to cover the line 56% of the time, while the 6.5-run over/under is expected to go over 57% of the time.
Guardians vs Tigers: Best Bets
- Head to Head: Detroit at $1.62 with TAB
- Line: Tigers -1.5 at $2.20 with TAB
- Total Runs: Over 6.5 at $1.91 with TAB
These Guardians vs Tigers predictions are based on complex modelling and gambling intelligence to provide you with the best possible advice around the clock.
Although the Guardians are more likely to cover the line, our best bet of Tigers -1.5 is based on the probability of that happening, as projected by our predictive analytics model, and the top odds available.
Guardians vs Tigers: Prediction
Stats Insider provides full betting coverage of the Cleveland vs Detroit game on Wednesday, including data-driven predictions and the best betting tips.
Our model updates frequently, so bookmark this article for the latest betting predictions before the Cleveland vs Detroit match-up.
As always, see our Best Bets for the best tips for every MLB game, plus predictions for a wide range of other sports.
Guardians vs Tigers: Essential Details
The match-up between the Guardians and Tigers at Progressive Field is scheduled to begin at 8:40am AEST on Wednesday.
- Teams: Cleveland Guardians vs Detroit Tigers
- Date: Wednesday 24 September 2025
- Time: 8:40am AEST
- Venue: Progressive Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Cleveland vs Detroit predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's crucial to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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