Guardians vs Royals Prediction and MLB Tips - 10 September 2025
Last updated: Sep 9, 2025, 10:36PM | Published: Sep 8, 2025, 6:30PM
The Cleveland Guardians will sqaure off with the Kansas City Royals in MLB action at Progressive Field on Wednesday, beginning at 8:40am AEST.
Joey Cantillo (4-3, 3.73 ERA) will start on the mound for the Guardians, while the Royals will counter with Noah Cameron (7-6, 3.03 ERA).
This article features Stats Insider's prediction and tips for the Guardians vs Royals game, as well as the latest betting odds in Australia.
Who Will Win?
Utilising advanced computer power and data, Stats Insider has simulated the outcome of Wednesday's Cleveland vs Kansas City MLB game 10,000 times.
Our proven predictive analytics model gives the Royals a 51% chance of winning against the Guardians at Progressive Field.
Guardians vs Royals: Odds
The latest betting odds in Australia for Wednesday's MLB game at Progressive Field are shown below:
- Head to Head: Guardians $1.91, Royals $1.91
- Line: Guardians -1.5 ($2.90), Royals +1.5 ($1.43)
- Total (Over/Under 7.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Guardians at $1.91 and the Royals at $1.91.
The Guardians are listed as 1.5-run favourites against the Royals, with odds of $2.90 available at TAB.
For the underdog Royals (+1.5) to cover the line, TAB offers odds of $1.43.
The over/under for total runs scored is set at 7.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Royals (+1.5) are predicted to cover the line 68% of the time, while the 7.5-run over/under is expected to stay under 52% of the time.
Guardians vs Royals: Best Bets
- Head to Head: Kansas City at $1.91 with TAB
- Line: Royals +1.5 at $1.43 with TAB
- Total Runs: Under 7.5 at $1.91 with TAB
Stats Insider's Guardians vs Royals predictions are based on complex simulations and wagering expertise to give you the best possible advice every time.
Guardians vs Royals: Prediction
Stats Insider provides full coverage of the Cleveland vs Kansas City game on Wednesday, including data-driven predictions and expert tips.
Our model updates regularly, so bookmark this page for the latest betting predictions before the Cleveland vs Kansas City game.
As always, see our Best Bets to get betting tips on every MLB game, plus predictions for a wide range of other sports.
Guardians vs Royals: Essential Details
The match-up between the Guardians and Royals at Progressive Field is scheduled to begin at 8:40am AEST on Wednesday.
- Teams: Cleveland Guardians vs Kansas City Royals
- Date: Wednesday 10 September 2025
- Time: 8:40am AEST
- Venue: Progressive Field
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Cleveland vs Kansas City predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's vital to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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