Guardians vs Cardinals Prediction and MLB Tips - 29 June 2025
Last updated: Jun 28, 2025, 8:11PM | Published: Jun 27, 2025, 7:34PM
The Cleveland Guardians will face the St. Louis Cardinals in MLB action at Progressive Field on Sunday, commencing at 6:10am AEST.
Slade Cecconi (3-3, 3.38 ERA) will be on the bump for the Guardians, pitting him against Miles Mikolas (4-5, 4.31 ERA) for the Cardinals.
This article features Stats Insider's prediction and tips for the Guardians vs Cardinals game, as well as the latest betting odds in Australia.
Who Will Win?
Based on trusted computer power and data, Stats Insider has simulated the result of Sunday's Cleveland vs St. Louis MLB game 10,000 times.
Our independent predictive analytics model gives the Guardians a 53% chance of winning against the Cardinals at Progressive Field.
Guardians vs Cardinals: Odds
The latest betting odds in Australia for Sunday's MLB game at Progressive Field are listed below:
- Head to Head: Guardians $1.80, Cardinals $2.05
- Line: Guardians -1.5 ($2.70), Cardinals +1.5 ($1.49)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Guardians at $1.80 and the Cardinals at $2.05.
The Guardians are listed as 1.5-run favourites against the Cardinals, with odds of $2.70 available at TAB.
For the underdog Cardinals (+1.5) to cover the line, TAB offers odds of $1.49.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Cardinals (+1.5) are predicted to cover the line 65% of the time, while the 8.5-run over/under is expected to stay under 53% of the time.
Guardians vs Cardinals: Betting Tips
- Head to Head: St. Louis at $2.05 with TAB
- Line: Cardinals +1.5 at $1.49 with TAB
- Total Runs: Under 8.5 at $1.91 with TAB
Today's Guardians vs Cardinals best bets are based on world-class simulations and betting experience to help you place smarter bets with your chosen online bookie.
While the Guardians have a higher chance of winning the game, betting on the Cardinals to win is our recommended option due to the edge found when comparing our data-driven probabilities to the odds currently on offer.
Taking advantage of the edges seen on Stats Insider is one of the keys to being profitable in the long run.
Guardians vs Cardinals: Prediction
Stats Insider provides full coverage of the Cleveland vs St. Louis game on Sunday, including data-driven predictions and top betting tips.
Remember, our model updates regularly, so bookmark this article for the latest betting predictions before the Cleveland vs St. Louis game.
As always, see Stats Insider's Best Bets for betting tips on every MLB game, as well as predictions for a wide range of other sports.
Guardians vs Cardinals: Essential Details
The game between the Guardians and Cardinals at Progressive Field is scheduled to commence at 6:10am AEST on Sunday.
- Teams: Cleveland Guardians vs St. Louis Cardinals
- Date: Sunday 29 June 2025
- Time: 6:10am AEST
- Venue: Progressive Field
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cleveland vs St. Louis predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, so that you can make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's vital that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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