Guardians vs Cardinals Prediction and MLB Tips - 29 June 2025
Last updated: Jun 28, 2025, 11:40AM | Published: Jun 27, 2025, 7:34PM
The Cleveland Guardians will take on the St. Louis Cardinals in MLB action at Progressive Field on Sunday, starting at 6:10am AEST.
The Guardians will have Slade Cecconi (3-3, 3.38 ERA) start, while the Cardinals will counter with Miles Mikolas (4-5, 4.31 ERA).
This article features Stats Insider's prediction and tips for the Guardians vs Cardinals game, along with the latest betting odds in Australia.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the result of Sunday's Cleveland vs St. Louis MLB match-up 10,000 times.
Our leading predictive analytics model currently gives the Guardians a 53% chance of beating the Cardinals at Progressive Field.
Guardians vs Cardinals: Odds
The current betting odds in Australia for Sunday's MLB game at Progressive Field are shown here:
- Head to Head: Guardians $1.83, Cardinals $2.00
- Line: Guardians -1.5 ($2.65), Cardinals +1.5 ($1.50)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Guardians at $1.83 and the Cardinals at $2.00.
The Guardians are 1.5-run favourites against the Cardinals, with odds of $2.65 available at TAB.
For the underdog Cardinals (+1.5) to cover the line, TAB offers odds of $1.50.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 64% of the time, while the 8.5-run over/under is expected to stay under 51% of the time.
Guardians vs Cardinals: Betting Tips
- Head to Head: Cleveland at $1.83 with TAB
- Line: Cardinals +1.5 at $1.50 with TAB
- Total Runs: Under 8.5 at $1.91 with TAB
Our Guardians vs Cardinals predictions are based on market-leading modelling and wagering intelligence to help you place better bets with your chosen online bookie.
Guardians vs Cardinals: Prediction
Stats Insider provides full coverage of the Cleveland vs St. Louis game on Sunday, including data-driven predictions and live win probabilitiestips.
Our model updates regularly, so bookmark this article for the latest betting predictions before the Cleveland vs St. Louis match-up.
As always, see Stats Insider's Best Bets to get betting tips on every MLB game, as well as predictions for a wide range of other sports.
Guardians vs Cardinals: Essential Details
The game between the Guardians and Cardinals at Progressive Field is scheduled to begin at 6:10am AEST on Sunday.
- Teams: Cleveland Guardians vs St. Louis Cardinals
- Date: Sunday 29 June 2025
- Time: 6:10am AEST
- Venue: Progressive Field
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Cleveland vs St. Louis predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's vital to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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