Guardians vs Cardinals Prediction and MLB Tips - 28 June 2025
Last updated: Jun 27, 2025, 11:11PM | Published: Jun 26, 2025, 7:29PM
The Cleveland Guardians will take on the St. Louis Cardinals in MLB action at Progressive Field on Saturday, commencing at 9:10am AEST.
The Guardians will send Luis L. Ortiz (4-8, 4.30 ERA) to the mound, pitting him against Sonny Gray (7-2, 3.72 ERA) for the Cardinals.
This article features Stats Insider's free betting tips for the Guardians vs Cardinals game, plus the latest betting odds in Australia.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the outcome of Saturday's Cleveland vs St. Louis MLB match-up 10,000 times.
Our leading predictive analytics model currently gives the Cardinals a 54% chance of beating the Guardians at Progressive Field.
Guardians vs Cardinals: Odds
The latest betting odds in Australia for Saturday's MLB game at Progressive Field are shown here:
- Head to Head: Guardians $2.10, Cardinals $1.77
- Line: Guardians +1.5 ($1.67), Cardinals -1.5 ($2.25)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Guardians at $2.10 and the Cardinals at $1.77.
The Guardians are 1.5-run underdogs against the Cardinals, with odds of $1.67 available at TAB.
For the favourite Cardinals (-1.5) to cover the line, TAB offers odds of $2.25.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Guardians (+1.5) are predicted to cover the line 59% of the time, while the 8.5-run over/under is expected to stay under 52% of the time.
Guardians vs Cardinals: Best Bets
- Head to Head: Cleveland at $2.10 with TAB
- Line: Guardians +1.5 at $1.67 with TAB
- Total Runs: Under 8.5 at $1.91 with TAB
Stats Insider's Guardians vs Cardinals predictions are based on world-class simulations and betting experience to provide you with the best possible advice 24/7.
While the Cardinals have a higher chance of winning the game, betting on the Guardians to win is our recommended option due to the edge found when comparing our data-led probabilities to the odds currently available.
Taking advantage of the edges seen on Stats Insider is one of the keys to being profitable in the long run.
Guardians vs Cardinals: Prediction
Stats Insider provides full betting coverage of the Cleveland vs St. Louis game on Saturday, including data-driven predictions and top betting tips.
Remember, our model updates frequently, so refresh this article for the latest betting predictions before the Cleveland vs St. Louis game.
As always, see our Best Bets for the best tips on every MLB game, as well as predictions for a wide range of other sports.
Guardians vs Cardinals: Essential Details
The game between the Guardians and Cardinals at Progressive Field is scheduled to start at 9:10am AEST on Saturday.
- Teams: Cleveland Guardians vs St. Louis Cardinals
- Date: Saturday 28 June 2025
- Time: 9:10am AEST
- Venue: Progressive Field
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Cleveland vs St. Louis predictions are based on 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's crucial to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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