Giants vs Chargers Prediction and Preview - NFL Week 4, 2025
Last updated: Sep 28, 2025, 5:03PM | Published: Sep 21, 2025, 4:01AM
The New York Giants will take on the favoured Los Angeles Chargers in NFL Week 4 action at MetLife Stadium on Monday, commencing at 3:00am AEST.
This article features Stats Insider's best betting tips for the Giants vs Chargers game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Using trusted machine learning and data, Stats Insider has simulated the outcome of Monday's NY Giants vs LA Chargers NFL game 10,000 times.
Our proven predictive analytics model currently gives the Chargers a 72% chance of beating the Giants in Week 4 of the NFL season.
Giants vs Chargers: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at MetLife Stadium are listed below:
- Head to Head: Giants $3.25, Chargers $1.36
- Line: Giants +6 ($1.91), Chargers -6 ($1.91)
- Total (Over/Under 42.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Giants at $3.25 and the Chargers at $1.36.
The Giants are listed as 6-point underdogs against the Chargers, with odds of $1.91 available at Bet365.
For the favourite Chargers (-6) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 42.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Chargers (-6) are predicted to cover the line 53% of the time, while the 42.5-point over/under is expected to go over 57% of the time.
Giants vs Chargers: Best Bets
- Head to Head: LA Chargers at $1.36 with Bet365
- Line: Chargers -6 at $1.91 with Bet365
- Total Points: Over 42.5 at $1.91 with Bet365
If you see a 🔥, that means it's one of Stats Insider's best tips of the day across all sports.
Our Giants vs Chargers predictions are based on world-class modelling and wagering experience to help you place more informed bets with your chosen online bookie.
Giants vs Chargers: Prediction
Stats Insider's predicted final score for Giants vs Chargers at MetLife Stadium in Week 4 is the Chargers winning 24-18.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the NY Giants vs LA Chargers game in Week 4, including data-driven predictions and expert tips.
Get expert analysis from the US with Dimers' in-depth Giants vs Chargers prediction.
18+. Odds correct at time of publishing and subject to change.Giants vs Chargers: TD Scorer Tips
Who will score an anytime touchdown in Giants vs Chargers? The latest data is in.
According to Stats Insider, Los Angeles' Omarion Hampton is the most likely player to score the first TD in Giants vs Chargers.
Hampton has a 15.5% chance of scoring the first TD at MetLife Stadium, while the Chargers RB has a 53.3% chance of reaching the end zone at any point in the game.
Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Giants First TD Tips
- Cam Skattebo: 11.6% probability
- Malik Nabers: 7.6% probability
- Wan'Dale Robinson: 4.4% probability
- Jaxson Dart: 3.7% probability
- Devin Singletary: 3.2% probability
Chargers First TD Tips
- Omarion Hampton: 15.5% probability
- Quentin Johnston: 8.1% probability
- Keenan Allen: 7.8% probability
- Ladd McConkey: 7.3% probability
- Hassan Haskins: 3.9% probability
Anytime Touchdown Scorer Tips
Giants Anytime TD Tips
- Cam Skattebo: 46.4% probability
- Malik Nabers: 33.5% probability
- Wan'Dale Robinson: 21.2% probability
- Jaxson Dart: 18.1% probability
- Devin Singletary: 15.7% probability
Chargers Anytime TD Tips
- Omarion Hampton: 53.3% probability
- Quentin Johnston: 32.7% probability
- Keenan Allen: 31.6% probability
- Ladd McConkey: 30.0% probability
- Hassan Haskins: 17.4% probability
Giants-Chargers Projected Player Stats
Of the starting quarterbacks, the Giants' Jaxson Dart is projected for 198 passing yards, while the Chargers' Justin Herbert is expected to throw for 264 yards.
Giants Starting QB
- Jaxson Dart: 198 projected passing yards
Chargers Starting QB
- Justin Herbert: 264 projected passing yards
Giants Rushing Yards
- Cam Skattebo: 59 projected yards
- Jaxson Dart: 29 projected yards
- Devin Singletary: 20 projected yards
Chargers Rushing Yards
- Omarion Hampton: 72 projected yards
- Justin Herbert: 18 projected yards
- Hassan Haskins: 17 projected yards
Giants Receiving Yards
- Malik Nabers: 73 projected yards
- Wan'Dale Robinson: 45 projected yards
- Darius Slayton: 25 projected yards
- Cam Skattebo: 23 projected yards
- Theo Johnson: 23 projected yards
Chargers Receiving Yards
- Ladd McConkey: 67 projected yards
- Keenan Allen: 57 projected yards
- Quentin Johnston: 57 projected yards
- Oronde Gadsden: 27 projected yards
- Omarion Hampton: 22 projected yards
Remember, our model updates frequently, so bookmark this article for the latest betting tips before the NY Giants vs LA Chargers match-up.
As always, see Stats Insider's Best Bets to get the best tips on every NFL game, plus predictions for a wide range of other sports.
Giants vs Chargers: Week 4 Essential Details
The NFL Week 4 game between the Giants and Chargers at MetLife Stadium is scheduled to begin at 3:00am AEST on Monday.
- Teams: New York Giants vs Los Angeles Chargers
- Date: Monday 29 September 2025
- Time: 3:00am AEST
- Venue: MetLife Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our NY Giants vs LA Chargers predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's crucial that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on NFL
Stats Insider is your go-to source for betting on the NFL in Australia, with the latest NFL betting news, tips for every NFL game, and Super Bowl probabilities for the NFL.
