Giants vs Cardinals Prediction and MLB Tips - 25 September 2025
Last updated: Sep 25, 2025, 1:45AM | Published: Sep 23, 2025, 7:31PM
The San Francisco Giants will sqaure off with the St. Louis Cardinals in Game of the League Series at Oracle Park on Thursday, commencing at 11:45am AEST.
The Giants will have JT Brubaker (0-0, 3.65 ERA) start, up against Sonny Gray (14-8, 4.33 ERA) for the Cardinals.
This article features Stats Insider's best betting tips for the Giants vs Cardinals game, as well as the latest betting odds in Australia.
Who Will Win?
Using advanced computer power and data, Stats Insider has simulated the outcome of Thursday's San Francisco vs St. Louis MLB match-up 10,000 times.
Our independent predictive analytics model currently gives the Cardinals a 52% chance of defeating the Giants at Oracle Park.
Giants vs Cardinals: Odds
The latest betting odds in Australia for Thursday's MLB game at Oracle Park are listed here:
- Head to Head: Giants $1.95, Cardinals $1.87
- Line: Giants +1.5 ($1.56), Cardinals -1.5 ($2.50)
- Total (Over/Under 7.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Giants at $1.95 and the Cardinals at $1.87.
The Giants are 1.5-run underdogs against the Cardinals, with odds of $1.56 available at TAB.
For the favourite Cardinals (-1.5) to cover the line, TAB offers odds of $2.50.
The over/under for total runs scored is set at 7.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Giants (+1.5) are predicted to cover the line 61% of the time, while the 7.5-run over/under is expected to go over 55% of the time.
Giants vs Cardinals: Best Bets
- Head to Head: St. Louis at $1.87 with TAB
- Line: Cardinals -1.5 at $2.50 with TAB
- Total Runs: Over 7.5 at $1.91 with TAB
Stats Insider's Giants vs Cardinals best bets are based on market-leading simulations and wagering experience to help you place smarter bets with your chosen online bookie.
Even though the Giants are more likely to cover the line, our best bet of Cardinals -1.5 is based on the probability of that happening, as projected by our predictive analytics model, and the top odds available.
Giants vs Cardinals: Prediction
Stats Insider provides full betting coverage of the San Francisco vs St. Louis game on Thursday, including data-driven predictions and expert tips.
Remember, our model updates frequently, so bookmark this article for the latest betting tips before the San Francisco vs St. Louis game.
As always, see Stats Insider's Best Bets for betting tips for every MLB game, as well as predictions for a wide range of other sports.
Giants vs Cardinals: Essential Details
The match-up between the Giants and Cardinals at Oracle Park is scheduled to start at 11:45am AEST on Thursday.
- Teams: San Francisco Giants vs St. Louis Cardinals
- Date: Thursday 25 September 2025
- Time: 11:45am AEST
- Venue: Oracle Park
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our San Francisco vs St. Louis predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's important to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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