Giants vs Cardinals Prediction and MLB Tips - 24 September 2025
Last updated: Sep 24, 2025, 1:46AM | Published: Sep 22, 2025, 7:29PM
The San Francisco Giants will take on the St. Louis Cardinals in Game of the League Series at Oracle Park on Wednesday, commencing at 11:45am AEST.
The Giants will have Logan Webb (14-11, 3.27 ERA) start, while the Cardinals are going with Andre Pallante (6-15, 5.29 ERA).
This article features Stats Insider's free betting tips for the Giants vs Cardinals game, as well as the latest betting odds in Australia.
Who Will Win?
Utilising trusted machine learning and data, Stats Insider has simulated the outcome of Wednesday's San Francisco vs St. Louis MLB match-up 10,000 times.
Our proven predictive analytics model gives the Giants a 63% chance of winning against the Cardinals at Oracle Park.
Giants vs Cardinals: Odds
The current betting odds in Australia for Wednesday's MLB game at Oracle Park are shown below:
- Head to Head: Giants $1.49, Cardinals $2.69
- Line: Giants -1.5 ($2.08), Cardinals +1.5 ($1.76)
- Total (Over/Under 7.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Giants at $1.49 and the Cardinals at $2.69.
The Giants are 1.5-run favourites against the Cardinals, with odds of $2.08 available at TAB.
For the underdog Cardinals (+1.5) to cover the line, TAB offers odds of $1.76.
The over/under for total runs scored is set at 7.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 56% of the time, while the 7.5-run over/under is expected to go over 54% of the time.
Giants vs Cardinals: Betting Tips
- Head to Head: St. Louis at $2.69 with TAB
- Line: Cardinals +1.5 at $1.76 with TAB
- Total Runs: Over 7.5 at $1.91 with TAB
Our Giants vs Cardinals best bets are based on market-leading simulations and gambling experience to provide you with the best possible advice every time.
While the Giants have a higher chance of winning the game, betting on the Cardinals to win is our recommended option because of the 1.7% edge found when comparing our data-driven probabilities to the odds currently on offer.
Taking advantage of the edges seen here at Stats Insider is one of the keys to being a profitable sports bettor in the long run.
Giants vs Cardinals: Prediction
Stats Insider provides full coverage of the San Francisco vs St. Louis game on Wednesday, including data-driven predictions and top betting tips.
Remember, our model updates frequently, so keep checking this article for the latest betting analysis before the San Francisco vs St. Louis match-up.
As always, see Stats Insider's Best Bets for the best tips on every MLB game, plus predictions for a wide range of other sports.
Giants vs Cardinals: Essential Details
The game between the Giants and Cardinals at Oracle Park is scheduled to commence at 11:45am AEST on Wednesday.
- Teams: San Francisco Giants vs St. Louis Cardinals
- Date: Wednesday 24 September 2025
- Time: 11:45am AEST
- Venue: Oracle Park
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our San Francisco vs St. Louis predictions are based on 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our MLB predictions for betting purposes, it's vital that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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