Giants vs 49ers Prediction and Preview - NFL Week 9, 2025
Last updated: Nov 2, 2025, 6:01PM | Published: Oct 26, 2025, 4:01AM
The New York Giants will take on the San Francisco 49ers in NFL Week 9 action at MetLife Stadium on Monday, starting at 5:00am AEDT.
This article features Stats Insider's prediction and tips for the Giants vs 49ers game, plus the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the result of Monday's NY Giants vs San Francisco NFL match-up 10,000 times.
Our proven predictive analytics model currently gives the 49ers a 59% chance of defeating the Giants at MetLife Stadium.
Giants vs 49ers: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at MetLife Stadium are listed below:
- Head to Head: Giants $2.25, 49ers $1.67
- Line: Giants +2.5 ($1.91), 49ers -2.5 ($1.91)
- Total (Over/Under 47.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Giants at $2.25 and the 49ers at $1.67.
The Giants are 2.5-point underdogs against the 49ers, with odds of $1.91 available at Bet365.
For the favourite 49ers (-2.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 47.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the bookmakers have got it right and both the Giants and the 49ers have a 50% chance of covering the line.
The 47.5-point over/under is expected to is also considered an equal 50-50 chance of hitting.
Giants vs 49ers: Best Bets
- Head to Head: San Francisco at $1.67 with Bet365
- Line: 49ers -2.5 at $1.91 with Bet365
- Total Points: Under 47.5 at $1.91 with Bet365
Our Giants vs 49ers betting tips are based on world-class modelling and wagering experience to provide you with the best possible advice every day of the year.
Giants vs 49ers: Prediction
Stats Insider's predicted final score for Giants vs 49ers at MetLife Stadium in Week 9 is the 49ers winning 24-22.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the NY Giants vs San Francisco game in Week 9, including data-driven predictions and live win probabilitiestips.
Get expert analysis from the US with Dimers' in-depth Giants vs 49ers prediction.
18+. Odds correct at time of publishing and subject to change.Giants vs 49ers: TD Scorer Tips
Who will score the first touchdown in Giants vs 49ers? The latest data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first touchdown in Giants vs 49ers.
McCaffrey has a 17.4% chance of getting in for six first at MetLife Stadium, while the 49ers RB has a 63.2% chance of reaching the end zone at any point in the game.
Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Giants First TD Tips
- Tyrone Tracy: 8.9% probability
- Wan'Dale Robinson: 7.1% probability
- Theo Johnson: 6.1% probability
- Jaxson Dart: 5.8% probability
- Darius Slayton: 5.4% probability
49ers First TD Tips
- Christian McCaffrey: 17.4% probability
- George Kittle: 8.5% probability
- Jauan Jennings: 6.1% probability
- Kendrick Bourne: 4.3% probability
- Demarcus Robinson: 2.6% probability
Anytime Touchdown Scorer Tips
Giants Anytime TD Tips
- Tyrone Tracy: 39.2% probability
- Wan'Dale Robinson: 32.7% probability
- Theo Johnson: 28.7% probability
- Jaxson Dart: 27.7% probability
- Darius Slayton: 26.0% probability
49ers Anytime TD Tips
- Christian McCaffrey: 63.2% probability
- George Kittle: 38.8% probability
- Jauan Jennings: 29.7% probability
- Kendrick Bourne: 21.8% probability
- Demarcus Robinson: 14.0% probability
Giants-49ers Projected Player Stats
Of the starting quarterbacks, the Giants' Jaxson Dart is projected for 216 passing yards. The 49ers' Mac Jones is expected to throw for 245 yards.
Giants Starting QB
- Jaxson Dart: 216 projected passing yards
49ers Starting QB
- Mac Jones: 245 projected passing yards
Giants Rushing Yards
- Tyrone Tracy: 54 projected yards
- Jaxson Dart: 35 projected yards
- Devin Singletary: 20 projected yards
49ers Rushing Yards
- Christian McCaffrey: 84 projected yards
- Brian Robinson: 19 projected yards
- Mac Jones: 10 projected yards
Giants Receiving Yards
- Wan'Dale Robinson: 58 projected yards
- Darius Slayton: 45 projected yards
- Theo Johnson: 39 projected yards
- Tyrone Tracy: 22 projected yards
- Ray-Ray McCloud: 21 projected yards
49ers Receiving Yards
- Jauan Jennings: 55 projected yards
- George Kittle: 52 projected yards
- Christian McCaffrey: 49 projected yards
- Kendrick Bourne: 43 projected yards
- Demarcus Robinson: 24 projected yards
Remember, our model updates frequently, so keep checking this page for the latest betting predictions before the NY Giants vs San Francisco match-up.
As always, see our Best Bets for betting tips for every NFL game, as well as predictions for a wide range of other sports.
Giants vs 49ers: Week 9 Essential Details
The NFL Week 9 game between the Giants and 49ers at MetLife Stadium is scheduled to commence at 5:00am AEDT on Monday.
- Teams: New York Giants vs San Francisco 49ers
- Date: Monday 3 November 2025
- Time: 5:00am AEDT
- Venue: MetLife Stadium
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our NY Giants vs San Francisco predictions have been made based on 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our NFL predictions for betting purposes, it's important that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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