Diamondbacks vs Guardians Prediction and MLB Tips - 21 August 2025
Last updated: Aug 20, 2025, 7:36PM | Published: Aug 20, 2025, 3:32AM
The Arizona Diamondbacks will take on the Cleveland Guardians in MLB action at Chase Field on Thursday, beginning at 5:40am AEST.
Brandon Pfaadt (12-8, 5.08 ERA) will be on the bump for the Diamondbacks, up against Parker Messick (0-0, 0.00 ERA) for the Guardians.
This article features Stats Insider's prediction and tips for the Diamondbacks vs Guardians game, plus the latest betting odds in Australia.
Who Will Win?
Using trusted machine learning and data, Stats Insider has simulated the outcome of Thursday's Arizona vs Cleveland MLB match-up 10,000 times.
Our independent predictive analytics model gives the Diamondbacks a 51% chance of beating the Guardians at Chase Field.
Diamondbacks vs Guardians: Odds
The latest betting odds in Australia for Thursday's MLB game at Chase Field are listed below:
- Head to Head: Diamondbacks $1.83, Guardians $2.00
- Line: Diamondbacks -1.5 ($2.70), Guardians +1.5 ($1.49)
- Total (Over/Under 9 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Diamondbacks at $1.83 and the Guardians at $2.00.
The Diamondbacks are listed as 1.5-run favourites against the Guardians, with odds of $2.70 available at TAB.
For the underdog Guardians (+1.5) to cover the line, TAB offers odds of $1.49.
The over/under for total runs scored is set at 9 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Guardians (+1.5) are predicted to cover the line 67% of the time, while the 9-run over/under is expected to stay under 52% of the time.
Diamondbacks vs Guardians: Betting Tips
- Head to Head: Cleveland at $2.00 with TAB
- Line: Guardians +1.5 at $1.49 with TAB
- Total Runs: Under 9 at $1.91 with TAB
Our Diamondbacks vs Guardians predictions are based on market-leading modelling and betting experience to provide you with the best possible advice 24/7.
While the Diamondbacks have a higher chance of winning the game, betting on the Guardians to win is our preferred option due to the 1.6% edge found when comparing our data-driven probabilities to the odds currently on offer.
Taking advantage of the edges published here at Stats Insider is pivotal to being a profitable punter in the long run.
Diamondbacks vs Guardians: Prediction
Stats Insider provides full betting coverage of the Arizona vs Cleveland game on Thursday, including data-driven predictions and the best betting tips.
Our model updates regularly, so refresh this page for the latest betting tips before the Arizona vs Cleveland match-up.
As always, see Stats Insider's Best Bets to get betting tips for every MLB game, plus predictions for a wide range of other sports.
Diamondbacks vs Guardians: Essential Details
The match-up between the Diamondbacks and Guardians at Chase Field is scheduled to start at 5:40am AEST on Thursday.
- Teams: Arizona Diamondbacks vs Cleveland Guardians
- Date: Thursday 21 August 2025
- Time: 5:40am AEST
- Venue: Chase Field
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Arizona vs Cleveland predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's crucial that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on MLB
Stats Insider is your go-to source for betting on the MLB in Australia, with the latest MLB betting news, predictions for every MLB game, and futures probabilities for the MLB.
