Diamondbacks vs Guardians Prediction and MLB Tips - 20 August 2025

The Arizona Diamondbacks will sqaure off with the Cleveland Guardians in MLB action at Chase Field on Wednesday, beginning at 11:40am AEST.

The Diamondbacks will send Eduardo Rodriguez (5-7, 5.40 ERA) to the mound, while the Guardians are going with Tanner Bibee (9-9, 4.54 ERA).

This article features Stats Insider's top betting tips for the Diamondbacks vs Guardians game, plus the latest betting odds in Australia.

Who Will Win?

Based on advanced computer power and data, Stats Insider has simulated the outcome of Wednesday's Arizona vs Cleveland MLB game 10,000 times.

Our independent predictive analytics model currently gives the Diamondbacks a 53% chance of beating the Guardians at Chase Field.

Diamondbacks vs Guardians: Odds

The current betting odds in Australia for Wednesday's MLB game at Chase Field are shown below:

• Head to Head: Diamondbacks $1.83, Guardians $2.00
• Line: Diamondbacks -1.5 ($2.70), Guardians +1.5 ($1.49)
• Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, the bookmakers currently have the Diamondbacks at $1.83 and the Guardians at $2.00.

The Diamondbacks are listed as 1.5-run favourites against the Guardians, with odds of $2.70 available at TAB.

For the underdog Guardians (+1.5) to cover the line, TAB offers odds of $1.49.

The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's model, the Guardians (+1.5) are predicted to cover the line 65% of the time, while the 8.5-run over/under is expected to is considered an equal 50-50 chance of hitting.

Diamondbacks vs Guardians: Betting Tips

• Head to Head: Arizona at $1.83 with TAB
• Line: Guardians +1.5 at $1.49 with TAB
• Total Runs: Under 8.5 at $1.91 with TAB

Today's Diamondbacks vs Guardians betting tips are based on world-class simulations and wagering experience to bring you the best possible advice around the clock.

Diamondbacks vs Guardians: Prediction

Stats Insider provides full betting coverage of the Arizona vs Cleveland game on Wednesday, including data-driven predictions and expert tips.

Remember, our model updates regularly, so bookmark this article for the latest betting tips before the Arizona vs Cleveland match-up.

As always, see Stats Insider's Best Bets for betting tips on every MLB game, as well as predictions for a wide range of other sports.

Diamondbacks vs Guardians: Essential Details

The game between the Diamondbacks and Guardians at Chase Field is scheduled to begin at 11:40am AEST on Wednesday.

• Teams: Arizona Diamondbacks vs Cleveland Guardians
• Date: Wednesday 20 August 2025
• Time: 11:40am AEST
• Venue: Chase Field

All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.

Conclusion

Our Arizona vs Cleveland predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, so that you can make informed decisions with confidence.

If you decide to use our predictions for betting purposes, it's vital to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

More on MLB

Stats Insider is your go-to source for betting on the MLB in Australia, with the latest MLB betting news, tips for every MLB game, and futures odds for the MLB.