Diamondbacks vs Giants Prediction and MLB Tips - 17 September 2025
Last updated: Sep 17, 2025, 1:41AM | Published: Sep 16, 2025, 10:30PM
The Arizona Diamondbacks will sqaure off with the San Francisco Giants in MLB action at Chase Field on Wednesday, beginning at 11:40am AEST.
The Diamondbacks will send Eduardo Rodriguez (8-8, 4.98 ERA) to the mound, up against Tristan Beck (1-0, 4.88 ERA) for the Giants.
This article features Stats Insider's prediction and tips for the Diamondbacks vs Giants game, as well as the latest betting odds in Australia.
Who Will Win?
Based on trusted machine learning and data, Stats Insider has simulated the result of Wednesday's Arizona vs San Francisco MLB match-up 10,000 times.
Our independent predictive analytics model gives the Diamondbacks a 56% chance of beating the Giants at Chase Field.
Diamondbacks vs Giants: Odds
The current betting odds in Australia for Wednesday's MLB game at Chase Field are listed below:
- Head to Head: Diamondbacks $1.77, Giants $2.10
- Line: Diamondbacks -1.5 ($2.54), Giants +1.5 ($1.54)
- Total (Over/Under 9 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Diamondbacks at $1.77 and the Giants at $2.10.
The Diamondbacks are listed as 1.5-run favourites against the Giants, with odds of $2.54 available at TAB.
For the underdog Giants (+1.5) to cover the line, TAB offers odds of $1.54.
The over/under for total runs scored is set at 9 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Giants (+1.5) are predicted to cover the line 61% of the time, while the 9-run over/under is expected to go over 51% of the time.
Diamondbacks vs Giants: Betting Tips
- Head to Head: Arizona at $1.77 with TAB
- Line: Diamondbacks -1.5 at $2.54 with TAB
- Total Runs: Over 9 at $1.91 with TAB
Our Diamondbacks vs Giants predictions are based on detailed simulations and gambling intelligence to give you the best possible advice around the clock.
Although the Giants are more likely to cover the line, our best bet of Diamondbacks -1.5 is based on the probability of that happening, as projected by our predictive analytics model, and the top odds available.
Diamondbacks vs Giants: Prediction
Stats Insider provides full betting coverage of the Arizona vs San Francisco game on Wednesday, including data-driven predictions and the best betting tips.
Our model updates frequently, so refresh this page for the latest betting predictions before the Arizona vs San Francisco match-up.
As always, see our Best Bets for the best tips on every MLB game, as well as predictions for a wide range of other sports.
Diamondbacks vs Giants: Essential Details
The game between the Diamondbacks and Giants at Chase Field is scheduled to begin at 11:40am AEST on Wednesday.
- Teams: Arizona Diamondbacks vs San Francisco Giants
- Date: Wednesday 17 September 2025
- Time: 11:40am AEST
- Venue: Chase Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Arizona vs San Francisco predictions are based on 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, so that you can make informed decisions with confidence.
If you decide to use our MLB predictions for betting purposes, it's crucial to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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