Cubs vs Phillies Prediction and MLB Tips - 22 April 2026
Last updated: Apr 21, 2026, 2:55PM | Published: Apr 20, 2026, 6:31PM
The Chicago Cubs will face the Philadelphia Phillies in MLB action at Wrigley Field on Wednesday, beginning at 9:40am AEST.
Shota Imanaga (1-1, 2.46 ERA) will start on the mound for the Cubs, while the Phillies will counter with Jesús Luzardo (1-3, 7.94 ERA).
This article features Stats Insider's best betting tips for the Cubs vs Phillies game, along with the latest betting odds in Australia.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the result of Wednesday's Cubs vs Philadelphia MLB match-up 10,000 times.
Our independent predictive analytics model currently gives the Cubs a 53% chance of defeating the Phillies at Wrigley Field.
Cubs vs Phillies: Odds
The current betting odds in Australia for Wednesday's MLB game at Wrigley Field are shown here:
- Head to Head: Cubs $1.83, Phillies $2.00
- Line: Cubs -1.5 ($2.70), Phillies +1.5 ($1.49)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cubs at $1.83 and the Phillies at $2.00.
The Cubs are 1.5-run favourites against the Phillies, with odds of $2.70 available at TAB.
For the underdog Phillies (+1.5) to cover the line, TAB offers odds of $1.49.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Phillies (+1.5) are predicted to cover the line 64% of the time, while the 8.5-run over/under is expected to is considered an equal 50-50 chance of hitting.
Cubs vs Phillies: Best Bets
- Head to Head: Cubs at $1.83 with TAB
- Line: Cubs -1.5 at $2.70 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
These Cubs vs Phillies predictions are based on market-leading simulations and betting intelligence to provide you with the best possible advice around the clock.
Although the Phillies are more likely to cover the line, our best bet of Cubs -1.5 is based on the likelihood of that happening, as projected by our predictive analytics model, and the top odds available.
Cubs vs Phillies: Prediction
Stats Insider provides full betting coverage of the Cubs vs Philadelphia game on Wednesday, including data-driven predictions and the best betting tips.
Our model updates regularly, so refresh this page for the latest betting predictions before the Cubs vs Philadelphia match-up.
As always, see our Best Bets to get the best tips for every MLB game, as well as predictions for a wide range of other sports.
Cubs vs Phillies: Essential Details
The game between the Cubs and Phillies at Wrigley Field is scheduled to start at 9:40am AEST on Wednesday.
- Teams: Chicago Cubs vs Philadelphia Phillies
- Date: Wednesday 22 April 2026
- Time: 9:40am AEST
- Venue: Wrigley Field
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cubs vs Philadelphia predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's important that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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