Cubs vs Phillies Prediction and MLB Tips - 22 April 2026
Last updated: Apr 21, 2026, 11:40PM | Published: Apr 20, 2026, 6:31PM
The Chicago Cubs will take on the Philadelphia Phillies in MLB action at Wrigley Field on Wednesday, beginning at 9:40am AEST.
The Cubs will send Shota Imanaga (1-1, 2.46 ERA) to the mound, while the Phillies will counter with Jesús Luzardo (1-3, 7.94 ERA).
This article features Stats Insider's prediction and tips for the Cubs vs Phillies game, as well as the latest betting odds in Australia.
Who Will Win?
Based on trusted machine learning and data, Stats Insider has simulated the result of Wednesday's Cubs vs Philadelphia MLB match-up 10,000 times.
Our independent predictive analytics model gives the Cubs a 55% chance of defeating the Phillies at Wrigley Field.
Cubs vs Phillies: Odds
The current betting odds in Australia for Wednesday's MLB game at Wrigley Field are listed below:
- Head to Head: Cubs $1.77, Phillies $2.10
- Line: Cubs -1.5 ($2.60), Phillies +1.5 ($1.53)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cubs at $1.77 and the Phillies at $2.10.
The Cubs are listed as 1.5-run favourites against the Phillies, with odds of $2.60 available at TAB.
For the underdog Phillies (+1.5) to cover the line, TAB offers odds of $1.53.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Phillies (+1.5) are predicted to cover the line 62% of the time, while the 8.5-run over/under is expected to go over 51% of the time.
Cubs vs Phillies: Betting Tips
- Head to Head: Cubs at $1.77 with TAB
- Line: Cubs -1.5 at $2.60 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
Today's Cubs vs Phillies betting tips are based on market-leading simulations and gambling expertise to help you place smarter bets with your chosen online bookie.
Even though the Phillies are more likely to cover the line, our best bet of Cubs -1.5 is based on the likelihood of that happening, as suggested by our predictive analytics model, and the best odds available.
Cubs vs Phillies: Prediction
Stats Insider provides full betting coverage of the Cubs vs Philadelphia game on Wednesday, including data-driven predictions and expert tips.
Remember, our model updates regularly, so bookmark this page for the latest betting tips before the Cubs vs Philadelphia game.
As always, see our Best Bets for betting tips on every MLB game, plus predictions for a wide range of other sports.
Cubs vs Phillies: Essential Details
The game between the Cubs and Phillies at Wrigley Field is scheduled to start at 9:40am AEST on Wednesday.
- Teams: Chicago Cubs vs Philadelphia Phillies
- Date: Wednesday 22 April 2026
- Time: 9:40am AEST
- Venue: Wrigley Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Cubs vs Philadelphia predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's vital to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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