Cubs vs Padres Prediction and MLB Tips - 1 October 2025
Last updated: Sep 30, 2025, 7:09PM | Published: Sep 30, 2025, 7:33AM
The Chicago Cubs will face the San Diego Padres in Game of the League Series at Wrigley Field on Wednesday, commencing at 5:08am AEST.
The Cubs will have Matthew Boyd (0-0, 0.00 ERA) start, up against Nick Pivetta (0-0, 0.00 ERA) for the Padres.
This article features Stats Insider's best betting tips for the Cubs vs Padres game, as well as the latest betting odds in Australia.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the outcome of Wednesday's Cubs vs San Diego MLB game 10,000 times.
Our proven predictive analytics model gives the Cubs a 55% chance of beating the Padres at Wrigley Field.
Cubs vs Padres: Odds
The current betting odds in Australia for Wednesday's MLB game at Wrigley Field are shown here:
- Head to Head: Cubs $1.77, Padres $2.10
- Line: Cubs -1.5 ($2.75), Padres +1.5 ($1.48)
- Total (Over/Under 6.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cubs at $1.77 and the Padres at $2.10.
The Cubs are 1.5-run favourites against the Padres, with odds of $2.75 available at TAB.
For the underdog Padres (+1.5) to cover the line, TAB offers odds of $1.48.
The over/under for total runs scored is set at 6.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Padres (+1.5) are predicted to cover the line 64% of the time, while the 6.5-run over/under is expected to go over 64% of the time.
Cubs vs Padres: Best Bets
- Head to Head: Cubs at $1.77 with TAB
- Line: Cubs -1.5 at $2.75 with TAB
- Total Runs: Over 6.5 at $1.91 with TAB
These Cubs vs Padres betting tips are based on complex simulations and betting intelligence to help you place more informed bets with your chosen online bookie.
Although the Padres are more likely to cover the line, our best bet of Cubs -1.5 is based on the probability of that happening, as suggested by our predictive analytics model, and the top odds available.
Cubs vs Padres: Prediction
Stats Insider provides full coverage of the Cubs vs San Diego game on Wednesday, including data-driven predictions and expert tips.
Our model updates regularly, so bookmark this page for the latest betting analysis before the Cubs vs San Diego game.
As always, see our Best Bets for betting tips for every MLB game, as well as predictions for a wide range of other sports.
Cubs vs Padres: Essential Details
The match-up between the Cubs and Padres at Wrigley Field is scheduled to begin at 5:08am AEST on Wednesday.
- Teams: Chicago Cubs vs San Diego Padres
- Date: Wednesday 1 October 2025
- Time: 5:08am AEST
- Venue: Wrigley Field
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Cubs vs San Diego predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our MLB predictions for betting purposes, it's important to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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