Cubs vs Padres Prediction and MLB Tips - 1 October 2025
Last updated: Sep 30, 2025, 7:31AM | Published: Sep 30, 2025, 6:55AM
The Chicago Cubs will face the San Diego Padres in Game of the League Series at Wrigley Field on Wednesday, beginning at 5:08am AEST.
The Cubs will have Matthew Boyd (0-0, 0.00 ERA) start, while the Padres will counter with Nick Pivetta (0-0, 0.00 ERA).
This article features Stats Insider's prediction and tips for the Cubs vs Padres game, along with the latest betting odds in Australia.
Who Will Win?
Using trusted machine learning and data, Stats Insider has simulated the result of Wednesday's Cubs vs San Diego MLB match-up 10,000 times.
Our leading predictive analytics model currently gives the Cubs a 52% chance of winning against the Padres at Wrigley Field.
Cubs vs Padres: Odds
The latest betting odds in Australia for Wednesday's MLB game at Wrigley Field are shown here:
- Head to Head: Cubs $1.87, Padres $1.95
- Line: Cubs -1.5 ($2.85), Padres +1.5 ($1.44)
- Total (Over/Under 7 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cubs at $1.87 and the Padres at $1.95.
The Cubs are 1.5-run favourites against the Padres, with odds of $2.85 available at TAB.
For the underdog Padres (+1.5) to cover the line, TAB offers odds of $1.44.
The over/under for total runs scored is set at 7 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Padres (+1.5) are predicted to cover the line 65% of the time, while the 7-run over/under is expected to go over 62% of the time.
Cubs vs Padres: Best Bets
- Head to Head: Cubs at $1.87 with TAB
- Line: Cubs -1.5 at $2.85 with TAB
- Total Runs: Over 7 at $1.91 with TAB
Stats Insider's Cubs vs Padres best bets are based on market-leading simulations and gambling experience to bring you the best possible advice every day of the year.
Although the Padres are more likely to cover the line, our best bet of Cubs -1.5 is based on the chance of that happening, as suggested by our predictive analytics model, and the top odds available.
Cubs vs Padres: Prediction
Stats Insider provides full coverage of the Cubs vs San Diego game on Wednesday, including data-driven predictions and top betting tips.
Our model updates frequently, so refresh this article for the latest betting predictions before the Cubs vs San Diego game.
As always, see our Best Bets for the best tips on every MLB game, plus predictions for a wide range of other sports.
Cubs vs Padres: Essential Details
The match-up between the Cubs and Padres at Wrigley Field is scheduled to begin at 5:08am AEST on Wednesday.
- Teams: Chicago Cubs vs San Diego Padres
- Date: Wednesday 1 October 2025
- Time: 5:08am AEST
- Venue: Wrigley Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cubs vs San Diego predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's vital that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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