Cubs vs Cardinals Prediction and MLB Tips - 29 September 2025
Last updated: Sep 28, 2025, 7:21PM | Published: Sep 28, 2025, 4:29AM
The Chicago Cubs will face the St. Louis Cardinals in Game of the League Series at Wrigley Field on Monday, beginning at 5:20am AEST.
Javier Assad (3-1, 4.26 ERA) will start on the mound for the Cubs, up against Kyle Leahy (4-2, 3.18 ERA) for the Cardinals.
This article features Stats Insider's free betting tips for the Cubs vs Cardinals game, along with the latest betting odds in Australia.
Who Will Win?
Based on trusted computer power and data, Stats Insider has simulated the result of Monday's Cubs vs St. Louis MLB game 10,000 times.
Our proven predictive analytics model currently gives the Cubs a 58% chance of winning against the Cardinals at Wrigley Field.
Cubs vs Cardinals: Odds
The latest betting odds in Australia for Monday's MLB game at Wrigley Field are shown below:
- Head to Head: Cubs $1.67, Cardinals $2.25
- Line: Cubs -1.5 ($2.54), Cardinals +1.5 ($1.54)
- Total (Over/Under 7 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cubs at $1.67 and the Cardinals at $2.25.
The Cubs are 1.5-run favourites against the Cardinals, with odds of $2.54 available at TAB.
For the underdog Cardinals (+1.5) to cover the line, TAB offers odds of $1.54.
The over/under for total runs scored is set at 7 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Cardinals (+1.5) are predicted to cover the line 61% of the time, while the 7-run over/under is expected to go over 62% of the time.
Cubs vs Cardinals: Best Bets
- Head to Head: Cubs at $1.67 with TAB
- Line: Cubs -1.5 at $2.54 with TAB
- Total Runs: Over 7 at $1.91 with TAB
Stats Insider's Cubs vs Cardinals betting tips are based on market-leading modelling and betting intelligence to help you place more informed bets with your chosen online bookie.
Although the Cardinals are more likely to cover the line, our best bet of Cubs -1.5 is based on the chance of that happening, as suggested by our predictive analytics model, and the top odds available.
Cubs vs Cardinals: Prediction
Stats Insider provides full coverage of the Cubs vs St. Louis game on Monday, including data-driven predictions and expert tips.
Our model updates regularly, so keep checking this page for the latest betting tips before the Cubs vs St. Louis game.
As always, see our Best Bets for the best tips on every MLB game, as well as predictions for a wide range of other sports.
Cubs vs Cardinals: Essential Details
The match-up between the Cubs and Cardinals at Wrigley Field is scheduled to commence at 5:20am AEST on Monday.
- Teams: Chicago Cubs vs St. Louis Cardinals
- Date: Monday 29 September 2025
- Time: 5:20am AEST
- Venue: Wrigley Field
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cubs vs St. Louis predictions are based on 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, so that you can make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's vital to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on MLB
Stats Insider is your go-to source for betting on the MLB in Australia, with the latest MLB betting news, tips for every MLB game, and futures odds for the MLB.
