Cubs vs Cardinals Prediction and MLB Tips - 28 September 2025
Last updated: Sep 27, 2025, 6:15PM | Published: Sep 26, 2025, 8:30PM
The Chicago Cubs will sqaure off with the St. Louis Cardinals in Game of the League Series at Wrigley Field on Sunday, commencing at 4:20am AEST.
Jameson Taillon (10-7, 3.78 ERA) will start for the Cubs, up against Michael McGreevy (8-3, 4.35 ERA) for the Cardinals.
This article features Stats Insider's best betting tips for the Cubs vs Cardinals game, as well as the latest betting odds in Australia.
Who Will Win?
Based on trusted computer power and data, Stats Insider has simulated the result of Sunday's Cubs vs St. Louis MLB game 10,000 times.
Our proven predictive analytics model currently gives the Cubs a 60% chance of winning against the Cardinals at Wrigley Field.
Cubs vs Cardinals: Odds
The latest betting odds in Australia for Sunday's MLB game at Wrigley Field are shown below:
- Head to Head: Cubs $1.56, Cardinals $2.50
- Line: Cubs -1.5 ($2.14), Cardinals +1.5 ($1.74)
- Total (Over/Under 9.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cubs at $1.56 and the Cardinals at $2.50.
The Cubs are 1.5-run favourites against the Cardinals, with odds of $2.14 available at TAB.
For the underdog Cardinals (+1.5) to cover the line, TAB offers odds of $1.74.
The over/under for total runs scored is set at 9.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 57% of the time, while the 9.5-run over/under is expected to go over 53% of the time.
Cubs vs Cardinals: Betting Tips
- Head to Head: St. Louis at $2.50 with TAB
- Line: Cardinals +1.5 at $1.74 with TAB
- Total Runs: Over 9.5 at $1.91 with TAB
These Cubs vs Cardinals predictions are based on complex modelling and wagering experience to help you place smarter bets with your chosen online bookie.
While the Cubs have a higher chance of winning the game, betting on the Cardinals to win is our recommended option due to the 2.1% edge found when comparing our data-led probabilities to the odds currently available.
Making use of the edges seen on Stats Insider is one of the keys to being a profitable punter in the long run.
Cubs vs Cardinals: Prediction
Stats Insider provides full betting coverage of the Cubs vs St. Louis game on Sunday, including data-driven predictions and live win probabilitiestips.
Remember, our model updates frequently, so keep checking this article for the latest betting predictions before the Cubs vs St. Louis match-up.
As always, see our Best Bets to get betting tips on every MLB game, as well as predictions for a wide range of other sports.
Cubs vs Cardinals: Essential Details
The match-up between the Cubs and Cardinals at Wrigley Field is scheduled to start at 4:20am AEST on Sunday.
- Teams: Chicago Cubs vs St. Louis Cardinals
- Date: Sunday 28 September 2025
- Time: 4:20am AEST
- Venue: Wrigley Field
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cubs vs St. Louis predictions have been made thanks to 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you choose to use our MLB predictions for betting purposes, it's important that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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