Cubs vs Cardinals Prediction and MLB Tips - 27 September 2025
Last updated: Sep 26, 2025, 6:22PM | Published: Sep 26, 2025, 6:28AM
The Chicago Cubs will take on the St. Louis Cardinals in Game of the League Series at Wrigley Field on Saturday, starting at 4:20am AEST.
The Cubs will send Colin Rea (10-7, 4.10 ERA) to the mound, while the Cardinals will counter with Miles Mikolas (8-10, 4.76 ERA).
This article features Stats Insider's prediction and tips for the Cubs vs Cardinals game, as well as the latest betting odds in Australia.
Who Will Win?
Based on trusted computer power and data, Stats Insider has simulated the outcome of Saturday's Cubs vs St. Louis MLB match-up 10,000 times.
Our independent predictive analytics model currently gives the Cubs a 62% chance of beating the Cardinals at Wrigley Field.
Cubs vs Cardinals: Odds
The current betting odds in Australia for Saturday's MLB game at Wrigley Field are listed below:
- Head to Head: Cubs $1.54, Cardinals $2.55
- Line: Cubs -1.5 ($2.04), Cardinals +1.5 ($1.80)
- Total (Over/Under 9 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cubs at $1.54 and the Cardinals at $2.55.
The Cubs are 1.5-run favourites against the Cardinals, with odds of $2.04 available at TAB.
For the underdog Cardinals (+1.5) to cover the line, TAB offers odds of $1.80.
The over/under for total runs scored is set at 9 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Cardinals (+1.5) are predicted to cover the line 55% of the time, while the 9-run over/under is expected to go over 54% of the time.
Cubs vs Cardinals: Betting Tips
- Head to Head: St. Louis at $2.55 with TAB
- Line: Cardinals +1.5 at $1.80 with TAB
- Total Runs: Over 9 at $1.91 with TAB
Today's Cubs vs Cardinals best bets are based on world-class simulations and betting intelligence to help you place more informed bets with your chosen online bookie.
While the Cubs have a higher chance of winning the game, betting on the Cardinals to win is our preferred option because of the edge found when comparing our data-driven probabilities to the odds currently available.
Making use of the edges published on Stats Insider is pivotal to being a profitable punter in the long run.
Cubs vs Cardinals: Prediction
Stats Insider provides full coverage of the Cubs vs St. Louis game on Saturday, including data-driven predictions and live win probabilitiestips.
Our model updates regularly, so refresh this article for the latest betting predictions before the Cubs vs St. Louis game.
As always, see Stats Insider's Best Bets for betting tips for every MLB game, as well as predictions for a wide range of other sports.
Cubs vs Cardinals: Essential Details
The match-up between the Cubs and Cardinals at Wrigley Field is scheduled to commence at 4:20am AEST on Saturday.
- Teams: Chicago Cubs vs St. Louis Cardinals
- Date: Saturday 27 September 2025
- Time: 4:20am AEST
- Venue: Wrigley Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cubs vs St. Louis predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, so that you can make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's important that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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