Cubs vs Astros Prediction and MLB Tips - 25 May 2026
Last updated: May 25, 2026, 6:14AM | Published: May 23, 2026, 7:28PM
The Chicago Cubs will sqaure off with the Houston Astros in MLB action at Wrigley Field on Monday, commencing at 4:20am AEST.
The Cubs will have Shota Imanaga (4-4, 3.38 ERA) start, while the Astros are going with Peter Lambert (2-4, 3.57 ERA).
This article features Stats Insider's free betting tips for the Cubs vs Astros game, plus the latest betting odds in Australia.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the result of Monday's Cubs vs Houston MLB match-up 10,000 times.
Our proven predictive analytics model gives the Cubs a 58% chance of defeating the Astros at Wrigley Field.
Cubs vs Astros: Odds
The current betting odds in Australia for Monday's MLB game at Wrigley Field are shown here:
- Head to Head: Cubs $1.56, Astros $2.50
- Line: Cubs -1.5 ($2.29), Astros +1.5 ($1.65)
- Total (Over/Under 7 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cubs at $1.56 and the Astros at $2.50.
The Cubs are listed as 1.5-run favourites against the Astros, with odds of $2.29 available at TAB.
For the underdog Astros (+1.5) to cover the line, TAB offers odds of $1.65.
The over/under for total runs scored is set at 7 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Astros (+1.5) are predicted to cover the line 60% of the time, while the 7-run over/under is expected to go over 58% of the time.
Cubs vs Astros: Best Bets
- Head to Head: Houston at $2.50 with TAB
- Line: Astros +1.5 at $1.65 with TAB
- Total Runs: Over 7 at $1.91 with TAB
Today's Cubs vs Astros predictions are based on complex modelling and wagering experience to bring you the best possible advice around the clock.
While the Cubs have a higher chance of winning the game, betting on the Astros to win is our recommended option because of the 3.5% edge found when comparing our data-driven probabilities to the odds currently available.
Taking advantage of the edges seen here at Stats Insider is crucial to achieving long-term success as a punter.
Cubs vs Astros: Prediction
Stats Insider provides full coverage of the Cubs vs Houston game on Monday, including data-driven predictions and expert tips.
Remember, our model updates frequently, so keep checking this article for the latest betting predictions before the Cubs vs Houston match-up.
As always, see our Best Bets for the best tips for every MLB game, plus predictions for a wide range of other sports.
Cubs vs Astros: Essential Details
The game between the Cubs and Astros at Wrigley Field is scheduled to start at 4:20am AEST on Monday.
- Teams: Chicago Cubs vs Houston Astros
- Date: Monday 25 May 2026
- Time: 4:20am AEST
- Venue: Wrigley Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cubs vs Houston predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our MLB predictions for betting purposes, it's crucial to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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