Cowboys vs Chargers Prediction and Preview - NFL Week 16, 2025
Last updated: Dec 14, 2025, 5:50PM | Published: Dec 14, 2025, 5:05AM
The Dallas Cowboys will take on the Los Angeles Chargers in NFL Week 16 action at AT&T Stadium on Monday, December 22, beginning at 5:00am AEDT.
This article features Stats Insider's top betting tips for the Cowboys vs Chargers game, as well as the latest betting odds in Australia.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the outcome of Chargers vs Cowboys 10,000 times.
Our independent predictive analytics model gives the Cowboys a 57% chance of beating the Chargers at AT&T Stadium.
Cowboys vs Chargers: Odds
The current Bet365 betting odds in Australia for this NFL game at AT&T Stadium are shown here:
- Head to Head: Cowboys $1.74, Chargers $2.15
- Line: Cowboys -2.5 ($1.91), Chargers +2.5 ($1.91)
- Total (Over/Under 48.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Cowboys at $1.74 and the Chargers at $2.15.
The Cowboys are listed as 2.5-point favourites against the Chargers, with odds of $1.91 available at Bet365.
For the underdog Chargers (+2.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 48.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the bookmakers have got it right and both the Cowboys and the Chargers have a 50% chance of covering the line.
The 48.5-point over/under is expected to is also considered an equal 50-50 chance of hitting.
Cowboys vs Chargers: Best Bets
- Head to Head: Dallas at $1.74 with Bet365
- Line: Chargers +2.5 at $1.91 with Bet365
- Total Points: Under 48.5 at $1.91 with Bet365
Today's Cowboys vs Chargers best bets are based on complex modelling and gambling intelligence to give you the best possible advice every time.
Cowboys vs Chargers: Prediction
Stats Insider's predicted final score for Cowboys vs Chargers at AT&T Stadium in Week 16 is the Cowboys prevailing 25-23.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the Dallas vs LA Chargers game in Week 16, including data-driven predictions and free tips.
18+. Odds correct at time of publishing and subject to change.Remember, our model updates regularly, so keep checking this article for the latest betting tips before the Dallas vs LA Chargers match-up.
As always, see Stats Insider's Best Bets for the best tips for every NFL game, as well as predictions for a wide range of other sports.
Cowboys vs Chargers: Week 16 Essential Details
The NFL Week 16 match-up between the Cowboys and Chargers at AT&T Stadium is scheduled to commence at 5:00am AEDT on Monday, December 22.
- Teams: Dallas Cowboys vs Los Angeles Chargers
- Date: Monday 22 December 2025
- Time: 5:00am AEDT
- Venue: AT&T Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Dallas vs LA Chargers predictions have been made thanks to 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's crucial that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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