Cowboys vs 49ers Prediction and Preview - NFL Week 10, 2026

The Dallas Cowboys will take on the favoured San Francisco 49ers in NFL Week 10 action at AT&T Stadium on Monday, November 16, starting at 8:25am AEDT.

This article features Stats Insider's prediction and tips for the Cowboys vs 49ers game, plus the latest betting odds in Australia.

Who Will Win?

Using advanced computer power and data, Stats Insider has simulated the outcome of 49ers vs Cowboys 10,000 times.

Our proven predictive analytics model gives the 49ers a 66% chance of winning against the Cowboys in Week 10 of the NFL season.

Cowboys vs 49ers: Odds

The current Bet365 betting odds in Australia for this NFL game at AT&T Stadium are listed here:

• Head to Head: Cowboys $2.80, 49ers $1.45
• Line: Cowboys +4.5 ($1.91), 49ers -4.5 ($1.91)
• Total (Over/Under 55.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Cowboys at $2.80 and the 49ers at $1.45.

The Cowboys are listed as 4.5-point underdogs against the 49ers, with odds of $1.91 available at Bet365.

For the favourite 49ers (-4.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 55.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's model, the Cowboys (+4.5) are predicted to cover the line 52% of the time, while the 55.5-point over/under is expected to go over 51% of the time.

Cowboys vs 49ers: Betting Tips

• Head to Head: Dallas at $2.80 with Bet365
• Line: Cowboys +4.5 at $1.91 with Bet365
• Total Points: Over 55.5 at $1.91 with Bet365

These Cowboys vs 49ers best bets are based on market-leading simulations and wagering expertise to give you the best possible advice around the clock.

While the 49ers have a higher chance of winning the game, betting on the Cowboys to win is our preferred option because of the edge found when comparing our data-led probabilities to the odds currently on offer.

Taking advantage of the edges seen on Stats Insider is pivotal to being a profitable bettor in the long run.

Cowboys vs 49ers: Prediction

Stats Insider's predicted final score for Cowboys vs 49ers at AT&T Stadium in Week 10 is the 49ers winning 30-25.

This prediction is based on each team's average score following 10,000 game simulations.

Stats Insider provides full betting coverage of the Dallas vs San Francisco game in Week 10, including data-driven predictions and free tips.

Our model updates regularly, so keep checking this article for the latest betting analysis before the Dallas vs San Francisco game.

As always, see our Best Bets to get betting tips for every NFL game, plus predictions for a wide range of other sports.

Cowboys vs 49ers: Week 10 Essential Details

The NFL Week 10 match-up between the Cowboys and 49ers at AT&T Stadium is scheduled to start at 8:25am AEDT on Monday, November 16.

• Teams: Dallas Cowboys vs San Francisco 49ers
• Date: Monday 16 November 2026
• Time: 8:25am AEDT
• Venue: AT&T Stadium

All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.

Conclusion

Our Dallas vs San Francisco predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.

If you decide to use our predictions for betting purposes, it's important to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

More on NFL

Stats Insider is your go-to source for betting on the NFL in Australia, with the latest NFL betting news, predictions for every NFL game, and Super Bowl odds for the NFL.