Colts vs Raiders Prediction and Preview - NFL Week 5, 2025

The Indianapolis Colts will take on the Las Vegas Raiders in NFL Week 5 action at Lucas Oil Stadium on Monday, October 6, commencing at 4:00am AEDT.

This article features Stats Insider's free betting tips for the Colts vs Raiders game, along with the latest betting odds in Australia.

Who Will Win?

Using trusted machine learning and data, Stats Insider has simulated the outcome of Raiders vs Colts 10,000 times.

Our proven predictive analytics model gives the Colts a 57% chance of defeating the Raiders in Week 5 of the NFL season.

Colts vs Raiders: Odds

The current Bet365 betting odds in Australia for this NFL game at Lucas Oil Stadium are listed below:

• Head to Head: Colts $1.37, Raiders $3.20
• Line: Colts -6.5 ($1.91), Raiders +6.5 ($1.91)
• Total (Over/Under 48.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Colts at $1.37 and the Raiders at $3.20.

The Colts are 6.5-point favourites against the Raiders, with odds of $1.91 available at Bet365.

For the underdog Raiders (+6.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 48.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the Raiders (+6.5) are predicted to cover the line 83% of the time, while the 48.5-point over/under is expected to stay under 61% of the time.

Colts vs Raiders: Best Bets

• Head to Head: Las Vegas at $3.20 with Bet365
• Line: Raiders +6.5 at $1.91 with Bet365
• Total Points: Under 48.5 at $1.91 with Bet365

When you see a 🔥, that means you've found one of our best tips of the day across all sports.

Our Colts vs Raiders betting tips are based on complex simulations and gambling expertise to give you the best possible advice every day of the year.

While the Colts have a higher chance of winning the game, betting on the Raiders to win is our recommended option due to the 12.1% edge found when comparing our data-driven probabilities to the odds currently on offer.

Taking advantage of the edges published on Stats Insider is crucial to achieving long-term success as a bettor.

Colts vs Raiders: Prediction

Stats Insider's predicted final score for Colts vs Raiders at Lucas Oil Stadium in Week 5 is the Colts winning 22-21.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full betting coverage of the Indianapolis vs Las Vegas game in Week 5, including data-driven predictions and expert tips.

Our model updates frequently, so refresh this page for the latest betting analysis before the Indianapolis vs Las Vegas game.

As always, see our Best Bets for betting tips for every NFL game, as well as predictions for a wide range of other sports.

Colts vs Raiders: Week 5 Essential Details

The NFL Week 5 game between the Colts and Raiders at Lucas Oil Stadium is scheduled to start at 4:00am AEDT on Monday, October 6.

• Teams: Indianapolis Colts vs Las Vegas Raiders
• Date: Monday 6 October 2025
• Time: 4:00am AEDT
• Venue: Lucas Oil Stadium

All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.

Conclusion

Our Indianapolis vs Las Vegas predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.

If you decide to use our NFL predictions for betting purposes, it's vital to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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