Colts vs Jaguars Prediction and Preview - NFL Week 17, 2025
Last updated: Dec 28, 2025, 6:01PM | Published: Dec 21, 2025, 5:01AM
The Indianapolis Colts will face the favoured Jacksonville Jaguars in NFL Week 17 action at Lucas Oil Stadium on Monday, starting at 5:00am AEDT.
This article features Stats Insider's best betting tips for the Colts vs Jaguars game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the result of Monday's Indianapolis vs Jacksonville NFL match-up 10,000 times.
Our proven predictive analytics model gives the Jaguars a 63% chance of winning against the Colts in Week 17 of the NFL season.
Colts vs Jaguars: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Lucas Oil Stadium are listed here:
- Head to Head: Colts $2.80, Jaguars $1.45
- Line: Colts +4 ($1.91), Jaguars -4 ($1.91)
- Total (Over/Under 48.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Colts at $2.80 and the Jaguars at $1.45.
The Colts are listed as 4-point underdogs against the Jaguars, with odds of $1.91 available at Bet365.
For the favourite Jaguars (-4) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 48.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Colts (+4) are predicted to cover the line 51% of the time, while the 48.5-point over/under is expected to is considered an equal 50-50 chance of hitting.
Colts vs Jaguars: Betting Tips
- Head to Head: Indianapolis at $2.80 with Bet365
- Line: Colts +4 at $1.91 with Bet365
- Total Points: Under 48.5 at $1.91 with Bet365
Stats Insider's Colts vs Jaguars predictions are based on detailed modelling and wagering expertise to provide you with the best possible advice every time.
While the Jaguars have a higher chance of winning the game, betting on the Colts to win is our preferred option because of the 1.7% edge found when comparing our data-driven probabilities to the odds currently available.
Making use of the edges seen here at Stats Insider is crucial to being a profitable punter in the long run.
Colts vs Jaguars: Prediction
Stats Insider's predicted final score for Colts vs Jaguars at Lucas Oil Stadium in Week 17 is the Jaguars winning 26-22.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the Indianapolis vs Jacksonville game in Week 17, including data-driven predictions and expert tips.
For in-depth analysis from US experts,, check out Dimers' detailed Colts vs Jaguars prediction.
18+. Odds correct at time of publishing and subject to change.Colts vs Jaguars: TD Scorer Tips
Who will score the first touchdown in Colts vs Jaguars? The latest data is in.
According to Stats Insider, Indianapolis' Jonathan Taylor is the most likely player to score the first touchdown in Colts vs Jaguars.
Taylor has a 16.4% chance of getting in for six first at Lucas Oil Stadium, while the Colts RB has a 63.7% chance of reaching the end zone at any point in the game.
Scroll down for the full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Colts First TD Tips
- Jonathan Taylor: 16.4% probability
- Tyler Warren: 5.6% probability
- Michael Pittman: 5.1% probability
- Josh Downs: 4.8% probability
- Alec Pierce: 4.5% probability
Jaguars First TD Tips
- Travis Etienne: 14.8% probability
- Jakobi Meyers: 7.2% probability
- Trevor Lawrence: 6.1% probability
- Brian Thomas: 6.0% probability
- Parker Washington: 5.4% probability
Anytime Touchdown Scorer Tips
Colts Anytime TD Tips
- Jonathan Taylor: 63.7% probability
- Tyler Warren: 29.1% probability
- Michael Pittman: 27.0% probability
- Josh Downs: 25.6% probability
- Alec Pierce: 24.2% probability
Jaguars Anytime TD Tips
- Travis Etienne: 57.1% probability
- Jakobi Meyers: 33.6% probability
- Trevor Lawrence: 29.4% probability
- Brian Thomas: 29.1% probability
- Parker Washington: 26.6% probability
Colts-Jaguars Projected Player Stats
Of the starting quarterbacks, the Colts' Philip Rivers is projected for 222 passing yards. The Jaguars' Trevor Lawrence is expected to throw for 255 yards.
Colts Starting QB
- Philip Rivers: 222 projected passing yards
Jaguars Starting QB
- Trevor Lawrence: 255 projected passing yards
Colts Rushing Yards
- Jonathan Taylor: 81 projected yards
- Ameer Abdullah: 12 projected yards
- Philip Rivers: 2 projected yards
Jaguars Rushing Yards
- Travis Etienne: 66 projected yards
- Trevor Lawrence: 22 projected yards
- LeQuint Allen: 14 projected yards
Colts Receiving Yards
- Michael Pittman: 51 projected yards
- Tyler Warren: 49 projected yards
- Josh Downs: 43 projected yards
- Alec Pierce: 38 projected yards
- Jonathan Taylor: 21 projected yards
Jaguars Receiving Yards
- Jakobi Meyers: 64 projected yards
- Brian Thomas: 53 projected yards
- Parker Washington: 48 projected yards
- Brenton Strange: 42 projected yards
- Travis Etienne: 22 projected yards
Our model updates frequently, so keep checking this page for the latest betting analysis before the Indianapolis vs Jacksonville game.
As always, see our Best Bets for the best tips on every NFL game, plus predictions for a wide range of other sports.
Colts vs Jaguars: Week 17 Essential Details
The NFL Week 17 game between the Colts and Jaguars at Lucas Oil Stadium is scheduled to start at 5:00am AEDT on Monday.
- Teams: Indianapolis Colts vs Jacksonville Jaguars
- Date: Monday 29 December 2025
- Time: 5:00am AEDT
- Venue: Lucas Oil Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Indianapolis vs Jacksonville predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our NFL predictions for betting purposes, it's important to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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