Colts vs Jaguars Prediction and Preview - NFL Week 17, 2025

The Indianapolis Colts will sqaure off with the favoured Jacksonville Jaguars in NFL Week 17 action at Lucas Oil Stadium on Monday, December 29, commencing at 5:00am AEDT.

This article features Stats Insider's best betting tips for the Colts vs Jaguars game, plus the latest betting odds in Australia.

Who Will Win?

Utilising advanced computer power and data, Stats Insider has simulated the result of Jaguars vs Colts 10,000 times.

Our independent predictive analytics model gives the Jaguars a 68% chance of beating the Colts in Week 17 of the NFL season.

Colts vs Jaguars: Odds

The latest Bet365 betting odds in Australia for this NFL game at Lucas Oil Stadium are listed here:

• Head to Head: Colts $2.95, Jaguars $1.42
• Line: Colts +5.5 ($1.91), Jaguars -5.5 ($1.91)
• Total (Over/Under 45 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Colts at $2.95 and the Jaguars at $1.42.

The Colts are 5.5-point underdogs against the Jaguars, with odds of $1.91 available at Bet365.

For the favourite Jaguars (-5.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 45 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the Colts (+5.5) are predicted to cover the line 54% of the time, while the 45-point over/under is expected to stay under 51% of the time.

Colts vs Jaguars: Best Bets

• Head to Head: Indianapolis at $2.95 with Bet365
• Line: Colts +5.5 at $1.91 with Bet365
• Total Points: Under 45 at $1.91 with Bet365

Today's Colts vs Jaguars best bets are based on market-leading modelling and gambling intelligence to provide you with the best possible advice around the clock.

While the Jaguars have a higher chance of winning the game, betting on the Colts to win is our preferred option because of the edge found when comparing our data-driven probabilities to the odds currently on offer.

Making use of the edges seen here at Stats Insider is one of the keys to achieving long-term success as a sports bettor.

Colts vs Jaguars: Prediction

Stats Insider's predicted final score for Colts vs Jaguars at Lucas Oil Stadium in Week 17 is the Jaguars winning 24-20.

This prediction is based on each team's average score following 10,000 game simulations.

Stats Insider provides full coverage of the Indianapolis vs Jacksonville game in Week 17, including data-driven predictions and live win probabilitiestips.

Our model updates frequently, so bookmark this page for the latest betting tips before the Indianapolis vs Jacksonville match-up.

As always, see Stats Insider's Best Bets to get betting tips for every NFL game, as well as predictions for a wide range of other sports.

Colts vs Jaguars: Week 17 Essential Details

The NFL Week 17 game between the Colts and Jaguars at Lucas Oil Stadium is scheduled to start at 5:00am AEDT on Monday, December 29.

• Teams: Indianapolis Colts vs Jacksonville Jaguars
• Date: Monday 29 December 2025
• Time: 5:00am AEDT
• Venue: Lucas Oil Stadium

All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.

Conclusion

Our Indianapolis vs Jacksonville predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.

If you choose to use our NFL predictions for betting purposes, it's vital to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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