Colts vs Cardinals Prediction and Preview - NFL Week 6, 2025
Last updated: Oct 12, 2025, 5:01PM | Published: Oct 5, 2025, 4:01AM
The Indianapolis Colts will take on the Arizona Cardinals in NFL Week 6 action at Lucas Oil Stadium on Monday, commencing at 4:00am AEDT.
This article features Stats Insider's free betting tips for the Colts vs Cardinals game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on advanced computer power and data, Stats Insider has simulated the result of Monday's Indianapolis vs Arizona NFL match-up 10,000 times.
Our independent predictive analytics model gives the Colts a 78% chance of defeating the Cardinals in Week 6 of the NFL season.
Colts vs Cardinals: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Lucas Oil Stadium are listed here:
- Head to Head: Colts $1.24, Cardinals $4.25
- Line: Colts -9 ($1.91), Cardinals +9 ($1.91)
- Total (Over/Under 46.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Colts at $1.24 and the Cardinals at $4.25.
The Colts are listed as 9-point favourites against the Cardinals, with odds of $1.91 available at Bet365.
For the underdog Cardinals (+9) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 46.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+9) are predicted to cover the line 52% of the time, while the 46.5-point over/under is expected to stay under 53% of the time.
Colts vs Cardinals: Betting Tips
- Head to Head: Arizona at $4.25 with Bet365
- Line: Cardinals +9 at $1.91 with Bet365
- Total Points: Under 46.5 at $1.91 with Bet365
Today's Colts vs Cardinals predictions are based on market-leading modelling and gambling experience to help you place better bets with your chosen online bookie.
While the Colts have a higher chance of winning the game, betting on the Cardinals to win is our preferred option because of the edge identified when comparing our data-driven probabilities to the odds currently available.
Making use of the edges published on Stats Insider is one of the keys to achieving long-term success as a bettor.
Colts vs Cardinals: Prediction
Stats Insider's predicted final score for Colts vs Cardinals at Lucas Oil Stadium in Week 6 is the Colts winning 26-18.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the Indianapolis vs Arizona game in Week 6, including data-driven predictions and free betting tips.
For in-depth analysis from US experts,, check out Dimers' detailed Colts vs Cardinals prediction.
18+. Odds correct at time of publishing and subject to change.Colts vs Cardinals: TD Scorer Tips
Who will score an anytime touchdown in Colts vs Cardinals? The data is in.
According to Stats Insider, Indianapolis' Jonathan Taylor is the most likely player to score the first touchdown in Colts vs Cardinals.
Taylor has a 19.9% chance of scoring the first TD at Lucas Oil Stadium, while the Colts RB has a 63.4% chance of scoring an anytime touchdown.
Scroll down for our full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Colts First TD Tips
- Jonathan Taylor: 19.9% probability
- Daniel Jones: 7.4% probability
- Tyler Warren: 7.0% probability
- Michael Pittman: 6.6% probability
- Josh Downs: 4.3% probability
Cardinals First TD Tips
- Bam Knight: 6.8% probability
- Marvin Harrison: 6.4% probability
- Michael Carter: 5.6% probability
- Trey McBride: 5.4% probability
- Emari Demercado: 3.2% probability
Anytime Touchdown Scorer Tips
Colts Anytime TD Tips
- Jonathan Taylor: 63.4% probability
- Daniel Jones: 31.3% probability
- Tyler Warren: 29.7% probability
- Michael Pittman: 28.3% probability
- Josh Downs: 19.5% probability
Cardinals Anytime TD Tips
- Bam Knight: 31.5% probability
- Marvin Harrison: 30.2% probability
- Michael Carter: 26.9% probability
- Trey McBride: 26.2% probability
- Emari Demercado: 16.4% probability
Colts-Cardinals Projected Player Stats
Of the starting quarterbacks, the Colts' Daniel Jones is projected for 236 passing yards. The Cardinals' Jacoby Brissett is expected to throw for 193 yards.
Colts Starting QB
- Daniel Jones: 236 projected passing yards
Cardinals Starting QB
- Jacoby Brissett: 193 projected passing yards
Colts Rushing Yards
- Jonathan Taylor: 89 projected yards
- Daniel Jones: 20 projected yards
- DJ Giddens: 6 projected yards
Cardinals Rushing Yards
- Bam Knight: 38 projected yards
- Michael Carter: 32 projected yards
- Jacoby Brissett: 17 projected yards
Colts Receiving Yards
- Michael Pittman: 57 projected yards
- Tyler Warren: 54 projected yards
- Josh Downs: 44 projected yards
- Alec Pierce: 39 projected yards
- Jonathan Taylor: 20 projected yards
Cardinals Receiving Yards
- Trey McBride: 59 projected yards
- Marvin Harrison: 55 projected yards
- Michael Wilson: 27 projected yards
- Zay Jones: 15 projected yards
- Greg Dortch: 13 projected yards
Our model updates regularly, so keep checking this article for the latest betting predictions before the Indianapolis vs Arizona game.
As always, see Stats Insider's Best Bets to get betting tips for every NFL game, plus predictions for a wide range of other sports.
Colts vs Cardinals: Week 6 Essential Details
The NFL Week 6 match-up between the Colts and Cardinals at Lucas Oil Stadium is scheduled to commence at 4:00am AEDT on Monday.
- Teams: Indianapolis Colts vs Arizona Cardinals
- Date: Monday 13 October 2025
- Time: 4:00am AEDT
- Venue: Lucas Oil Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our Indianapolis vs Arizona predictions have been made after running 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's vital to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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