Colts vs Cardinals Prediction and Preview - NFL Week 6, 2025
Last updated: Oct 9, 2025, 7:52PM | Published: Oct 5, 2025, 4:01AM
The Indianapolis Colts will take on the Arizona Cardinals in NFL Week 6 action at Lucas Oil Stadium on Monday, beginning at 4:00am AEDT.
This article features Stats Insider's prediction and tips for the Colts vs Cardinals game, plus the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the result of Monday's Indianapolis vs Arizona NFL match-up 10,000 times.
Our proven predictive analytics model currently gives the Colts a 75% chance of winning against the Cardinals at Lucas Oil Stadium.
Colts vs Cardinals: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Lucas Oil Stadium are listed below:
- Head to Head: Colts $1.28, Cardinals $3.75
- Line: Colts -7 ($1.91), Cardinals +7 ($1.91)
- Total (Over/Under 47 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Colts at $1.28 and the Cardinals at $3.75.
The Colts are listed as 7-point favourites against the Cardinals, with odds of $1.91 available at Bet365.
For the underdog Cardinals (+7) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 47 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Colts (-7) are predicted to cover the line 55% of the time, while the 47-point over/under is expected to stay under 52% of the time.
Colts vs Cardinals: Best Bets
- Head to Head: Arizona at $3.75 with Bet365
- Line: Colts -7 at $1.91 with Bet365
- Total Points: Under 47 at $1.91 with Bet365
Today's Colts vs Cardinals predictions are based on market-leading modelling and betting expertise to help you place better bets with your chosen online bookie.
While the Colts have a higher chance of winning the game, betting on the Cardinals to win is our preferred option because of the edge found when comparing our data-driven probabilities to the odds currently on offer.
Making use of the edges seen on Stats Insider is one of the keys to achieving long-term profitability.
Colts vs Cardinals: Prediction
Stats Insider's predicted final score for Colts vs Cardinals at Lucas Oil Stadium in Week 6 is the Colts winning 26-19.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the Indianapolis vs Arizona game in Week 6, including data-driven predictions and top betting tips.
18+. Odds correct at time of publishing and subject to change.Colts vs Cardinals: TD Scorer Tips
Who will score the first touchdown in Colts vs Cardinals? The data is in.
According to Stats Insider, Indianapolis' Jonathan Taylor is the most likely player to score the first touchdown in Colts vs Cardinals.
Taylor has a 16.8% chance of getting in for six first at Lucas Oil Stadium, while the Colts RB has a 61.0% chance of scoring an anytime touchdown.
Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Colts First TD Tips
- Jonathan Taylor: 16.8% probability
- Tyler Warren: 6.5% probability
- Michael Pittman: 6.2% probability
- Daniel Jones: 6.2% probability
- Josh Downs: 4.1% probability
Cardinals First TD Tips
- Michael Carter: 7.6% probability
- Marvin Harrison: 6.7% probability
- Trey McBride: 5.5% probability
- Kyler Murray: 4.0% probability
- Emari Demercado: 3.7% probability
Anytime Touchdown Scorer Tips
Colts Anytime TD Tips
- Jonathan Taylor: 61.0% probability
- Tyler Warren: 30.7% probability
- Michael Pittman: 29.6% probability
- Daniel Jones: 29.3% probability
- Josh Downs: 20.8% probability
Cardinals Anytime TD Tips
- Michael Carter: 35.0% probability
- Marvin Harrison: 31.5% probability
- Trey McBride: 26.7% probability
- Kyler Murray: 20.3% probability
- Emari Demercado: 19.1% probability
Colts-Cardinals Projected Player Stats
Of the starting quarterbacks, the Colts' Daniel Jones is projected for 234 passing yards, while the Cardinals' Kyler Murray is expected to throw for 203 yards.
Colts Starting QB
- Daniel Jones: 234 projected passing yards
Cardinals Starting QB
- Kyler Murray: 203 projected passing yards
Colts Rushing Yards
- Jonathan Taylor: 88 projected yards
- Daniel Jones: 22 projected yards
- DJ Giddens: 11 projected yards
Cardinals Rushing Yards
- Michael Carter: 52 projected yards
- Kyler Murray: 37 projected yards
- Emari Demercado: 19 projected yards
Colts Receiving Yards
- Michael Pittman: 58 projected yards
- Tyler Warren: 54 projected yards
- Josh Downs: 45 projected yards
- Alec Pierce: 38 projected yards
- Jonathan Taylor: 21 projected yards
Cardinals Receiving Yards
- Trey McBride: 60 projected yards
- Marvin Harrison: 55 projected yards
- Michael Wilson: 30 projected yards
- Michael Carter: 14 projected yards
- Zay Jones: 13 projected yards
Our model updates frequently, so refresh this page for the latest betting analysis before the Indianapolis vs Arizona game.
As always, see Stats Insider's Best Bets to get betting tips for every NFL game, as well as predictions for a wide range of other sports.
Colts vs Cardinals: Week 6 Essential Details
The NFL Week 6 game between the Colts and Cardinals at Lucas Oil Stadium is scheduled to start at 4:00am AEDT on Monday.
- Teams: Indianapolis Colts vs Arizona Cardinals
- Date: Monday 13 October 2025
- Time: 4:00am AEDT
- Venue: Lucas Oil Stadium
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our Indianapolis vs Arizona predictions have been made based on 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's crucial to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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