Colts vs Broncos Prediction and Preview - NFL Week 2, 2025
Last updated: Sep 14, 2025, 8:05PM | Published: Sep 9, 2025, 7:21AM
The Indianapolis Colts will sqaure off with the Denver Broncos in NFL Week 2 action at Lucas Oil Stadium on Monday, beginning at 6:05am AEST.
This article features Stats Insider's prediction and tips for the Colts vs Broncos game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the outcome of Monday's Indianapolis vs Denver NFL game 10,000 times.
Our independent predictive analytics model currently gives the Broncos a 59% chance of winning against the Colts at Lucas Oil Stadium.
Colts vs Broncos: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Lucas Oil Stadium are shown below:
- Head to Head: Colts $2.00, Broncos $1.83
- Line: Colts +1 ($1.91), Broncos -1 ($1.91)
- Total (Over/Under 43.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Colts at $2.00 and the Broncos at $1.83.
The Colts are listed as 1-point underdogs against the Broncos, with odds of $1.91 available at Bet365.
For the favourite Broncos (-1) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 43.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Broncos (-1) are predicted to cover the line 55% of the time, while the 43.5-point over/under is expected to stay under 54% of the time.
Colts vs Broncos: Best Bets
- Head to Head: Denver at $1.83 with Bet365
- Line: Broncos -1 at $1.91 with Bet365
- Total Points: Under 43.5 at $1.91 with Bet365
If you see a 🔥, that means you've found one of Stats Insider's best bets for today across any sport.
Our Colts vs Broncos predictions are based on world-class modelling and betting intelligence to provide you with the best possible advice around the clock.
Colts vs Broncos: Prediction
Stats Insider's predicted final score for Colts vs Broncos at Lucas Oil Stadium in Week 2 is the Broncos winning 22-20.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the Indianapolis vs Denver game in Week 2, including data-driven predictions and live win probabilitiestips.
For in-depth analysis from US experts,, check out Dimers' detailed Colts vs Broncos prediction.
18+. Odds correct at time of publishing and subject to change.Colts vs Broncos: TD Scorer Tips
Who will score an anytime touchdown in Colts vs Broncos? The data is in.
According to Stats Insider, Indianapolis' Jonathan Taylor is the most likely player to score the first touchdown in Colts vs Broncos.
Taylor has a 13.9% chance of scoring the first TD at Lucas Oil Stadium, while the Colts RB has a 52.7% chance of scoring an anytime touchdown.
Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Colts First TD Tips
- Jonathan Taylor: 13.9% probability
- Michael Pittman: 5.2% probability
- Daniel Jones: 5.2% probability
- Tyler Warren: 5.1% probability
- Josh Downs: 3.8% probability
Broncos First TD Tips
- J.K. Dobbins: 10.5% probability
- Courtland Sutton: 7.9% probability
- RJ Harvey: 5.8% probability
- Marvin Mims: 4.3% probability
- Evan Engram: 4.2% probability
Anytime Touchdown Scorer Tips
Colts Anytime TD Tips
- Jonathan Taylor: 52.7% probability
- Michael Pittman: 24.5% probability
- Daniel Jones: 24.3% probability
- Tyler Warren: 23.8% probability
- Josh Downs: 18.5% probability
Broncos Anytime TD Tips
- J.K. Dobbins: 42.0% probability
- Courtland Sutton: 33.7% probability
- RJ Harvey: 26.1% probability
- Marvin Mims: 20.0% probability
- Evan Engram: 19.7% probability
Colts-Broncos Projected Player Stats
Of the starting quarterbacks, the Colts' Daniel Jones is projected for 208 passing yards. The Broncos' Bo Nix is expected to throw for 233 yards.
Colts Starting QB
- Daniel Jones: 208 projected passing yards
Broncos Starting QB
- Bo Nix: 233 projected passing yards
Colts Rushing Yards
- Jonathan Taylor: 77 projected yards
- Daniel Jones: 30 projected yards
- DJ Giddens: 9 projected yards
Broncos Rushing Yards
- J.K. Dobbins: 53 projected yards
- RJ Harvey: 33 projected yards
- Bo Nix: 22 projected yards
Colts Receiving Yards
- Michael Pittman: 51 projected yards
- Tyler Warren: 46 projected yards
- Josh Downs: 42 projected yards
- Alec Pierce: 28 projected yards
- Jonathan Taylor: 18 projected yards
Broncos Receiving Yards
- Courtland Sutton: 67 projected yards
- Marvin Mims: 36 projected yards
- Troy Franklin: 36 projected yards
- Evan Engram: 33 projected yards
- J.K. Dobbins: 14 projected yards
Remember, our model updates frequently, so bookmark this page for the latest betting tips before the Indianapolis vs Denver match-up.
As always, see Stats Insider's Best Bets to get betting tips for every NFL game, plus predictions for a wide range of other sports.
Colts vs Broncos: Week 2 Essential Details
The NFL Week 2 game between the Colts and Broncos at Lucas Oil Stadium is scheduled to commence at 6:05am AEST on Monday.
- Teams: Indianapolis Colts vs Denver Broncos
- Date: Monday 15 September 2025
- Time: 6:05am AEST
- Venue: Lucas Oil Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Indianapolis vs Denver predictions are based on 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's important to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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