Colts vs Broncos Prediction and Preview - NFL Week 2, 2025
Last updated: Sep 9, 2025, 7:10AM | Published: Sep 9, 2025, 5:10AM
The Indianapolis Colts will sqaure off with the Denver Broncos in NFL Week 2 action at Lucas Oil Stadium on Monday, starting at 6:05am AEST.
This article features Stats Insider's free betting tips for the Colts vs Broncos game, as well as the latest betting odds in Australia.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the outcome of Monday's Indianapolis vs Denver NFL match-up 10,000 times.
Our independent predictive analytics model currently gives the Broncos a 59% chance of defeating the Colts in Week 2 of the NFL season.
Colts vs Broncos: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Lucas Oil Stadium are shown here:
- Head to Head: Colts $2.15, Broncos $1.74
- Line: Colts +2.5 ($1.91), Broncos -2.5 ($1.91)
- Total (Over/Under 42.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Colts at $2.15 and the Broncos at $1.74.
The Colts are listed as 2.5-point underdogs against the Broncos, with odds of $1.91 available at Bet365.
For the favourite Broncos (-2.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 42.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Broncos (-2.5) are predicted to cover the line 64% of the time, while the 42.5-point over/under is expected to go over 58% of the time.
Colts vs Broncos: Best Bets
- Head to Head: Denver at $1.74 with Bet365
- Line: Broncos -2.5 at $1.91 with Bet365
- Total Points: Over 42.5 at $1.91 with Bet365
If you see a 🔥, that means it's one of our best bets of the day across any sport.
These Colts vs Broncos predictions are based on complex modelling and gambling intelligence to provide you with the best possible advice 24/7/365.
Colts vs Broncos: Prediction
Stats Insider's predicted final score for Colts vs Broncos at Lucas Oil Stadium in Week 2 is the Broncos winning 22-20.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the Indianapolis vs Denver game in Week 2, including data-driven predictions and expert tips.
18+. Odds correct at time of publishing and subject to change.Our model updates frequently, so bookmark this page for the latest betting predictions before the Indianapolis vs Denver match-up.
As always, see Stats Insider's Best Bets for the best tips on every NFL game, as well as predictions for a wide range of other sports.
Colts vs Broncos: Week 2 Essential Details
The NFL Week 2 game between the Colts and Broncos at Lucas Oil Stadium is scheduled to commence at 6:05am AEST on Monday.
- Teams: Indianapolis Colts vs Denver Broncos
- Date: Monday 15 September 2025
- Time: 6:05am AEST
- Venue: Lucas Oil Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Indianapolis vs Denver predictions have been made after running 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's vital that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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