Chiefs vs Colts Prediction and Preview - NFL Week 2, 2026
Last updated: Sep 21, 2026, 12:20AM | Published: Sep 14, 2026, 4:01AM
The Kansas City Chiefs will sqaure off with the Indianapolis Colts in NFL Week 2 action at Arrowhead Stadium on Monday, commencing at 10:20am AEST.
This article features Stats Insider's best betting tips for the Chiefs vs Colts game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the result of Monday's Kansas City vs Indianapolis NFL game 10,000 times.
Our leading predictive analytics model currently gives the Chiefs a 69% chance of winning against the Colts in Week 2 of the NFL season.
Chiefs vs Colts: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Arrowhead Stadium are listed here:
- Head to Head: Chiefs $1.36, Colts $3.30
- Line: Chiefs -5.5 ($1.91), Colts +5.5 ($1.91)
- Total (Over/Under 45.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Chiefs at $1.36 and the Colts at $3.30.
The Chiefs are listed as 5.5-point favourites against the Colts, with odds of $1.91 available at Bet365.
For the underdog Colts (+5.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 45.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the bookmakers have got it right and both the Chiefs and the Colts have a 50% chance of covering the line.
The 45.5-point over/under is expected to stay under 52% of the time.
Chiefs vs Colts: Betting Tips
- Head to Head: Indianapolis at $3.30 with Bet365
- Line: Colts +5.5 at $1.91 with Bet365
- Total Points: Under 45.5 at $1.91 with Bet365
These Chiefs vs Colts predictions are based on market-leading modelling and betting experience to help you place more informed bets with your chosen online bookie.
While the Chiefs have a higher chance of winning the game, betting on the Colts to win is our recommended option because of the edge identified when comparing our data-driven probabilities to the odds currently on offer.
Taking advantage of the edges published on Stats Insider is crucial to achieving long-term profitability.
Chiefs vs Colts: Prediction
Stats Insider's predicted final score for Chiefs vs Colts at Arrowhead Stadium in Week 2 is the Chiefs winning 25-19.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the Kansas City vs Indianapolis game in Week 2, including data-driven predictions and top betting tips.
18+. Odds correct at time of publishing and subject to change.Chiefs vs Colts: TD Scorer Tips
Who will score an anytime touchdown in Chiefs vs Colts? The data is in.
According to Stats Insider, Kansas City's Kenneth Walker is the most likely player to score the first touchdown in Chiefs vs Colts.
Walker has a 17.0% chance of scoring the first TD at Arrowhead Stadium, while the Chiefs RB has a 56.5% chance of scoring an anytime touchdown.
Scroll down for our full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Chiefs First TD Tips
- Kenneth Walker: 17.0% probability
- Rashee Rice: 8.1% probability
- Travis Kelce: 6.3% probability
- Xavier Worthy: 5.6% probability
- Patrick Mahomes: 4.2% probability
Colts First TD Tips
- Jonathan Taylor: 14.3% probability
- Tyler Warren: 5.8% probability
- Alec Pierce: 5.5% probability
- Josh Downs: 4.5% probability
- Keenan Allen: 3.4% probability
Anytime Touchdown Scorer Tips
Chiefs Anytime TD Tips
- Kenneth Walker: 56.5% probability
- Rashee Rice: 32.6% probability
- Travis Kelce: 26.7% probability
- Xavier Worthy: 24.1% probability
- Patrick Mahomes: 18.4% probability
Colts Anytime TD Tips
- Jonathan Taylor: 55.0% probability
- Tyler Warren: 27.5% probability
- Alec Pierce: 26.2% probability
- Josh Downs: 22.3% probability
- Keenan Allen: 17.0% probability
Chiefs-Colts Projected Player Stats
Of the starting quarterbacks, the Chiefs' Patrick Mahomes is projected for 228 passing yards. The Colts' Daniel Jones is expected to throw for 222 yards.
Chiefs Starting QB
- Patrick Mahomes: 228 projected passing yards
Colts Starting QB
- Daniel Jones: 222 projected passing yards
Chiefs Rushing Yards
- Kenneth Walker: 86 projected yards
- Patrick Mahomes: 21 projected yards
- Emmett Johnson: 17 projected yards
Colts Rushing Yards
- Jonathan Taylor: 82 projected yards
- Daniel Jones: 13 projected yards
- Seth McGowan: 12 projected yards
Chiefs Receiving Yards
- Rashee Rice: 53 projected yards
- Xavier Worthy: 45 projected yards
- Travis Kelce: 44 projected yards
- Kenneth Walker: 24 projected yards
- Tyquan Thornton: 23 projected yards
Colts Receiving Yards
- Alec Pierce: 50 projected yards
- Josh Downs: 47 projected yards
- Tyler Warren: 46 projected yards
- Keenan Allen: 37 projected yards
- Jonathan Taylor: 20 projected yards
Our model updates regularly, so keep checking this page for the latest betting predictions before the Kansas City vs Indianapolis match-up.
As always, see our Best Bets for betting tips on every NFL game, plus predictions for a wide range of other sports.
Chiefs vs Colts: Week 2 Essential Details
The NFL Week 2 game between the Chiefs and Colts at Arrowhead Stadium is scheduled to commence at 10:20am AEST on Monday.
- Teams: Kansas City Chiefs vs Indianapolis Colts
- Date: Monday 21 September 2026
- Time: 10:20am AEST
- Venue: Arrowhead Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Kansas City vs Indianapolis predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.
If you decide to use our NFL predictions for betting purposes, it's crucial that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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