Chiefs vs Colts Prediction and Preview - NFL Week 12, 2025
Last updated: Nov 24, 2025, 3:50AM | Published: Nov 16, 2025, 5:01AM
The Kansas City Chiefs will face the Indianapolis Colts in NFL Week 12 action at GEHA Field at Arrowhead Stadium on Monday, starting at 5:00am AEDT.
This article features Stats Insider's best betting tips for the Chiefs vs Colts game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the result of Monday's Kansas City vs Indianapolis NFL match-up 10,000 times.
Our proven predictive analytics model currently gives the Chiefs a 56% chance of defeating the Colts in Week 12 of the NFL season.
Chiefs vs Colts: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at GEHA Field at Arrowhead Stadium are shown below:
- Head to Head: Chiefs $1.54, Colts $2.55
- Line: Chiefs -3 ($1.91), Colts +3 ($1.91)
- Total (Over/Under 50 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Chiefs at $1.54 and the Colts at $2.55.
The Chiefs are listed as 3-point favourites against the Colts, with odds of $1.91 available at Bet365.
For the underdog Colts (+3) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 50 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Colts (+3) are predicted to cover the line 61% of the time, while the 50-point over/under is expected to go over 51% of the time.
Chiefs vs Colts: Best Bets
- Head to Head: Indianapolis at $2.55 with Bet365
- Line: Colts +3 at $1.91 with Bet365
- Total Points: Over 50 at $1.91 with Bet365
If you see a 🔥, that means it's one of our best tips for today across all sports.
These Chiefs vs Colts betting tips are based on world-class simulations and wagering intelligence to help you place better bets with your chosen online bookie.
While the Chiefs have a higher chance of winning the game, betting on the Colts to win is our recommended option due to the 4.4% edge identified when comparing our data-driven probabilities to the odds currently available.
Taking advantage of the edges seen here at Stats Insider is one of the keys to achieving long-term success as a punter.
Chiefs vs Colts: Prediction
Stats Insider's predicted final score for Chiefs vs Colts at GEHA Field at Arrowhead Stadium in Week 12 is the Chiefs winning 26-24.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the Kansas City vs Indianapolis game in Week 12, including data-driven predictions and live win probabilitiestips.
Get expert analysis from the US with Dimers' in-depth Chiefs vs Colts prediction.
18+. Odds correct at time of publishing and subject to change.Chiefs vs Colts: TD Scorer Tips
Who will score an anytime touchdown in Chiefs vs Colts? The data is in.
According to Stats Insider, Indianapolis' Jonathan Taylor is the most likely player to score the first TD in Chiefs vs Colts.
Taylor has a 17.1% chance of getting in for six first at GEHA Field at Arrowhead Stadium, while the Colts RB has a 67.8% chance of reaching the end zone at any point in the game.
Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Chiefs First TD Tips
- Kareem Hunt: 11.4% probability
- Rashee Rice: 9.3% probability
- Travis Kelce: 6.7% probability
- Xavier Worthy: 5.3% probability
- Patrick Mahomes: 3.9% probability
Colts First TD Tips
- Jonathan Taylor: 17.1% probability
- Tyler Warren: 5.0% probability
- Michael Pittman: 4.6% probability
- Alec Pierce: 4.0% probability
- Daniel Jones: 3.8% probability
Anytime Touchdown Scorer Tips
Chiefs Anytime TD Tips
- Kareem Hunt: 52.1% probability
- Rashee Rice: 45.2% probability
- Travis Kelce: 35.2% probability
- Xavier Worthy: 28.9% probability
- Patrick Mahomes: 22.1% probability
Colts Anytime TD Tips
- Jonathan Taylor: 67.8% probability
- Tyler Warren: 28.4% probability
- Michael Pittman: 26.3% probability
- Alec Pierce: 23.5% probability
- Daniel Jones: 22.3% probability
Chiefs-Colts Projected Player Stats
Of the starting quarterbacks, the Chiefs' Patrick Mahomes is projected for 273 passing yards, while the Colts' Daniel Jones is expected to throw for 243 yards.
Chiefs Starting QB
- Patrick Mahomes: 273 projected passing yards
Colts Starting QB
- Daniel Jones: 243 projected passing yards
Chiefs Rushing Yards
- Kareem Hunt: 57 projected yards
- Patrick Mahomes: 26 projected yards
- Brashard Smith: 8 projected yards
Colts Rushing Yards
- Jonathan Taylor: 87 projected yards
- Daniel Jones: 20 projected yards
- Ameer Abdullah: 7 projected yards
Chiefs Receiving Yards
- Rashee Rice: 78 projected yards
- Travis Kelce: 53 projected yards
- Xavier Worthy: 46 projected yards
- Hollywood Brown: 28 projected yards
- JuJu Smith-Schuster: 15 projected yards
Colts Receiving Yards
- Alec Pierce: 59 projected yards
- Michael Pittman: 56 projected yards
- Tyler Warren: 52 projected yards
- Josh Downs: 39 projected yards
- Jonathan Taylor: 22 projected yards
Our model updates frequently, so keep checking this article for the latest betting tips before the Kansas City vs Indianapolis match-up.
As always, see Stats Insider's Best Bets for betting tips for every NFL game, as well as predictions for a wide range of other sports.
Chiefs vs Colts: Week 12 Essential Details
The NFL Week 12 match-up between the Chiefs and Colts at GEHA Field at Arrowhead Stadium is scheduled to start at 5:00am AEDT on Monday.
- Teams: Kansas City Chiefs vs Indianapolis Colts
- Date: Monday 24 November 2025
- Time: 5:00am AEDT
- Venue: GEHA Field at Arrowhead Stadium
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our Kansas City vs Indianapolis predictions have been made based on 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our NFL predictions for betting purposes, it's vital that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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