Chargers vs Colts Prediction and Preview - NFL Week 7, 2025

The Los Angeles Chargers will take on the Indianapolis Colts in NFL Week 7 action at SoFi Stadium on Monday, beginning at 7:05am AEDT.

This article features Stats Insider's prediction and tips for the Chargers vs Colts game, plus the latest betting odds and touchdown scorer tips.

Who Will Win?

Using advanced machine learning and data, Stats Insider has simulated the result of Monday's LA Chargers vs Indianapolis NFL game 10,000 times.

Our proven predictive analytics model gives the Chargers a 55% chance of beating the Colts in Week 7 of the NFL season.

Chargers vs Colts: Odds

The latest Bet365 betting odds in Australia for Monday's NFL game at SoFi Stadium are listed here:

• Head to Head: Chargers $1.77, Colts $2.10
• Line: Chargers -1.5 ($1.91), Colts +1.5 ($1.91)
• Total (Over/Under 48.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Chargers at $1.77 and the Colts at $2.10.

The Chargers are 1.5-point favourites against the Colts, with odds of $1.91 available at Bet365.

For the underdog Colts (+1.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 48.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the bookmakers have got it right and both the Chargers and the Colts have a 50% chance of covering the line.

The 48.5-point over/under is expected to is also considered an equal 50-50 chance of hitting.

Chargers vs Colts: Best Bets

• Head to Head: LA Chargers at $1.77 with Bet365
• Line: Colts +1.5 at $1.91 with Bet365
• Total Points: Under 48.5 at $1.91 with Bet365

These Chargers vs Colts best bets are based on detailed modelling and betting experience to provide you with the best possible advice around the clock.

Chargers vs Colts: Prediction

Stats Insider's predicted final score for Chargers vs Colts at SoFi Stadium in Week 7 is the Chargers winning 25-23.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full coverage of the LA Chargers vs Indianapolis game in Week 7, including data-driven predictions and live win probabilitiestips.

18+. Odds correct at time of publishing and subject to change.

Chargers vs Colts: TD Scorer Tips

Who will score an anytime touchdown in Chargers vs Colts? The latest data is in.

According to Stats Insider, Indianapolis' Jonathan Taylor is the most likely player to score the first TD in Chargers vs Colts.

Taylor has a 16.5% chance of scoring the first TD at SoFi Stadium, while the Colts RB has a 61.7% chance of reaching the end zone at any point during the game.

Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.

First Touchdown Scorer Tips

Chargers First TD Tips

• Hassan Haskins: 10.5% probability
• Quentin Johnston: 8.6% probability
• Kimani Vidal: 8.4% probability
• Keenan Allen: 7.6% probability
• Ladd McConkey: 6.8% probability

Colts First TD Tips

• Jonathan Taylor: 16.5% probability
• Daniel Jones: 7.3% probability
• Tyler Warren: 6.3% probability
• Michael Pittman: 4.8% probability
• Josh Downs: 3.2% probability

Anytime Touchdown Scorer Tips

Chargers Anytime TD Tips

• Hassan Haskins: 46.0% probability
• Quentin Johnston: 39.6% probability
• Kimani Vidal: 38.9% probability
• Keenan Allen: 36.1% probability
• Ladd McConkey: 32.9% probability

Colts Anytime TD Tips

• Jonathan Taylor: 61.7% probability
• Daniel Jones: 34.7% probability
• Tyler Warren: 30.5% probability
• Michael Pittman: 24.2% probability
• Josh Downs: 17.0% probability

Chargers-Colts Projected Player Stats

Of the starting quarterbacks, the Chargers' Justin Herbert is projected for 265 passing yards. The Colts' Daniel Jones is expected to throw for 219 yards.

Chargers Starting QB

• Justin Herbert: 265 projected passing yards

Colts Starting QB

• Daniel Jones: 219 projected passing yards

Chargers Rushing Yards

• Kimani Vidal: 56 projected yards
• Hassan Haskins: 23 projected yards
• Justin Herbert: 17 projected yards

Colts Rushing Yards

• Jonathan Taylor: 81 projected yards
• Daniel Jones: 28 projected yards
• DJ Giddens: 11 projected yards

Chargers Receiving Yards

• Ladd McConkey: 58 projected yards
• Quentin Johnston: 57 projected yards
• Keenan Allen: 54 projected yards
• Oronde Gadsden: 26 projected yards
• Kimani Vidal: 16 projected yards

Colts Receiving Yards

• Michael Pittman: 56 projected yards
• Tyler Warren: 49 projected yards
• Josh Downs: 35 projected yards
• Alec Pierce: 35 projected yards
• Jonathan Taylor: 20 projected yards

Remember, our model updates frequently, so keep checking this page for the latest betting predictions before the LA Chargers vs Indianapolis match-up.

As always, see our Best Bets to get the best tips on every NFL game, plus predictions for a wide range of other sports.

Chargers vs Colts: Week 7 Essential Details

The NFL Week 7 game between the Chargers and Colts at SoFi Stadium is scheduled to start at 7:05am AEDT on Monday.

• Teams: Los Angeles Chargers vs Indianapolis Colts
• Date: Monday 20 October 2025
• Time: 7:05am AEDT
• Venue: SoFi Stadium

All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.

Conclusion

Our LA Chargers vs Indianapolis predictions have been made after running 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.

If you choose to use our NFL predictions for betting purposes, it's vital to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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