Chargers vs Chiefs Prediction and Preview - NFL Week 1, 2025
Last updated: Sep 6, 2025, 12:11AM | Published: Aug 19, 2025, 6:16PM
The Los Angeles Chargers will face the Kansas City Chiefs in NFL Week 1 action at Corinthians Arena on Saturday, commencing at 10:00am AEST.
This article features Stats Insider's top betting tips for the Chargers vs Chiefs game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising trusted machine learning and data, Stats Insider has simulated the outcome of Saturday's LA Chargers vs Kansas City NFL match-up 10,000 times.
Our leading predictive analytics model currently gives the Chiefs a 59% chance of beating the Chargers in Week 1 of the NFL season.
Chargers vs Chiefs: Odds
The current Bet365 betting odds in Australia for Saturday's NFL game at Corinthians Arena are listed here:
- Head to Head: Chargers $2.45, Chiefs $1.59
- Line: Chargers +3 ($1.91), Chiefs -3 ($1.91)
- Total (Over/Under 47.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Chargers at $2.45 and the Chiefs at $1.59.
The Chargers are 3-point underdogs against the Chiefs, with odds of $1.91 available at Bet365.
For the favourite Chiefs (-3) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 47.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the bookmakers have got it right and both the Chargers and the Chiefs have a 50% chance of covering the line.
The 47.5-point over/under is expected to is also considered an equal 50-50 chance of hitting.
Chargers vs Chiefs: Betting Tips
- Head to Head: LA Chargers at $2.45 with Bet365
- Line: Chiefs -3 at $1.91 with Bet365
- Total Points: Under 47.5 at $1.91 with Bet365
These Chargers vs Chiefs best bets are based on detailed simulations and wagering intelligence to provide you with the best possible advice 24/7/365.
While the Chiefs have a higher chance of winning the game, betting on the Chargers to win is our recommended option because of the edge found when comparing our data-driven probabilities to the odds currently available.
Making use of the edges seen on Stats Insider is one of the keys to achieving long-term profitability.
Chargers vs Chiefs: Prediction
Stats Insider's predicted final score for Chargers vs Chiefs at Corinthians Arena in Week 1 is the Chiefs winning 24-22.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the LA Chargers vs Kansas City game in Week 1, including data-driven predictions and live win probabilitiestips.
18+. Odds correct at time of publishing and subject to change.Chargers vs Chiefs: TD Scorer Tips
Who will score the first touchdown in Chargers vs Chiefs? The latest data is in.
According to Stats Insider, Los Angeles' Omarion Hampton is the most likely player to score the first TD in Chargers vs Chiefs.
Hampton has a 10.3% chance of scoring the first TD at Corinthians Arena, while the Chargers RB has a 41.7% chance of scoring an anytime touchdown.
Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Chargers First TD Tips
- Omarion Hampton: 10.3% probability
- Ladd McConkey: 7.6% probability
- Najee Harris: 5.4% probability
- Keenan Allen: 4.8% probability
- Quentin Johnston: 3.9% probability
Chiefs First TD Tips
- Xavier Worthy: 9.9% probability
- Isiah Pacheco: 8.1% probability
- Travis Kelce: 6.9% probability
- Hollywood Brown: 5.7% probability
- Kareem Hunt: 5.4% probability
Anytime Touchdown Scorer Tips
Chargers Anytime TD Tips
- Omarion Hampton: 41.7% probability
- Ladd McConkey: 32.9% probability
- Najee Harris: 24.6% probability
- Keenan Allen: 22.2% probability
- Quentin Johnston: 18.3% probability
Chiefs Anytime TD Tips
- Xavier Worthy: 40.1% probability
- Isiah Pacheco: 34.3% probability
- Travis Kelce: 30.1% probability
- Hollywood Brown: 25.5% probability
- Kareem Hunt: 24.4% probability
Chargers-Chiefs Projected Player Stats
Of the starting quarterbacks, the Chargers' Justin Herbert is projected for 247 passing yards. The Chiefs' Patrick Mahomes is expected to throw for 256 yards.
Chargers Starting QB
- Justin Herbert: 247 projected passing yards
Chiefs Starting QB
- Patrick Mahomes: 256 projected passing yards
Chargers Rushing Yards
- Omarion Hampton: 54 projected yards
- Najee Harris: 26 projected yards
- Justin Herbert: 18 projected yards
Chiefs Rushing Yards
- Isiah Pacheco: 51 projected yards
- Kareem Hunt: 24 projected yards
- Patrick Mahomes: 20 projected yards
Chargers Receiving Yards
- Ladd McConkey: 73 projected yards
- Keenan Allen: 46 projected yards
- Quentin Johnston: 32 projected yards
- Tyler Conklin: 22 projected yards
- Will Dissly: 21 projected yards
Chiefs Receiving Yards
- Xavier Worthy: 65 projected yards
- Travis Kelce: 53 projected yards
- Hollywood Brown: 44 projected yards
- JuJu Smith-Schuster: 26 projected yards
- Noah Gray: 23 projected yards
Remember, our model updates frequently, so bookmark this page for the latest betting predictions before the LA Chargers vs Kansas City game.
As always, see our Best Bets to get betting tips for every NFL game, plus predictions for a wide range of other sports.
Chargers vs Chiefs: Week 1 Essential Details
The NFL Week 1 game between the Chargers and Chiefs at Corinthians Arena is scheduled to commence at 10:00am AEST on Saturday.
- Teams: Los Angeles Chargers vs Kansas City Chiefs
- Date: Saturday 6 September 2025
- Time: 10:00am AEST
- Venue: Corinthians Arena
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our LA Chargers vs Kansas City predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our NFL predictions for betting purposes, it's important to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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