Chargers vs Chiefs Prediction and Preview - NFL Week 1, 2025
Last updated: Aug 20, 2025, 1:16PM | Published: Aug 19, 2025, 6:16PM
The Los Angeles Chargers will sqaure off with the Kansas City Chiefs in NFL Week 1 action at Corinthians Arena on Saturday, September 6, starting at 10:00am AEST.
This article features Stats Insider's prediction and tips for the Chargers vs Chiefs game, along with the latest betting odds in Australia.
Who Will Win?
Based on trusted machine learning and data, Stats Insider has simulated the outcome of Chiefs vs Chargers 10,000 times.
Our independent predictive analytics model currently gives the Chiefs a 60% chance of defeating the Chargers at Corinthians Arena.
Chargers vs Chiefs: Odds
The latest Bet365 betting odds in Australia for this NFL game at Corinthians Arena are listed here:
- Head to Head: Chargers $2.50, Chiefs $1.54
- Line: Chargers +3 ($1.91), Chiefs -3 ($1.91)
- Total (Over/Under 45 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Chargers at $2.50 and the Chiefs at $1.54.
The Chargers are 3-point underdogs against the Chiefs, with odds of $1.91 available at Bet365.
For the favourite Chiefs (-3) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 45 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Chargers (+3) are predicted to cover the line 52% of the time, while the 45-point over/under is expected to go over 51% of the time.
Chargers vs Chiefs: Betting Tips
- Head to Head: LA Chargers at $2.50 with Bet365
- Line: Chargers +3 at $1.91 with Bet365
- Total Points: Over 45 at $1.91 with Bet365
Our Chargers vs Chiefs best bets are based on detailed modelling and wagering intelligence to help you place more informed bets with your chosen online bookie.
While the Chiefs have a higher chance of winning the game, betting on the Chargers to win is our recommended option due to the edge identified when comparing our data-driven probabilities to the odds currently available.
Making use of the edges published here at Stats Insider is one of the keys to achieving long-term profitability.
Chargers vs Chiefs: Prediction
Stats Insider's predicted final score for Chargers vs Chiefs at Corinthians Arena in Week 1 is the Chiefs winning 24-21.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the LA Chargers vs Kansas City game in Week 1, including data-driven predictions and live scorestips.
18+. Odds correct at time of publishing and subject to change.Our model updates frequently, so bookmark this article for the latest betting tips before the LA Chargers vs Kansas City game.
As always, see Stats Insider's Best Bets to get betting tips for every NFL game, as well as predictions for a wide range of other sports.
Chargers vs Chiefs: Week 1 Essential Details
The NFL Week 1 match-up between the Chargers and Chiefs at Corinthians Arena is scheduled to commence at 10:00am AEST on Saturday, September 6.
- Teams: Los Angeles Chargers vs Kansas City Chiefs
- Date: Saturday 6 September 2025
- Time: 10:00am AEST
- Venue: Corinthians Arena
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our LA Chargers vs Kansas City predictions are based on 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you decide to use our NFL predictions for betting purposes, it's crucial that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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