Chargers vs Chiefs Prediction and Preview - NFL Week 1, 2025

The Los Angeles Chargers will take on the Kansas City Chiefs in NFL Week 1 action at Corinthians Arena on Saturday, September 6, starting at 10:00am AEST.

This article features Stats Insider's prediction and tips for the Chargers vs Chiefs game, along with the latest betting odds in Australia.

Who Will Win?

Using advanced computer power and data, Stats Insider has simulated the result of Chiefs vs Chargers 10,000 times.

Our proven predictive analytics model gives the Chiefs a 60% chance of defeating the Chargers in Week 1 of the NFL season.

Chargers vs Chiefs: Odds

The current Bet365 betting odds in Australia for this NFL game at Corinthians Arena are listed here:

• Head to Head: Chargers $2.50, Chiefs $1.56
• Line: Chargers +3 ($1.91), Chiefs -3 ($1.91)
• Total (Over/Under 45 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Chargers at $2.50 and the Chiefs at $1.56.

The Chargers are 3-point underdogs against the Chiefs, with odds of $1.91 available at Bet365.

For the favourite Chiefs (-3) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 45 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the bookmakers have got it right and both the Chargers and the Chiefs have a 50% chance of covering the line.

The 45-point over/under is expected to go over 51% of the time.

Chargers vs Chiefs: Betting Tips

• Head to Head: LA Chargers at $2.50 with Bet365
• Line: Chiefs -3 at $1.91 with Bet365
• Total Points: Over 45 at $1.91 with Bet365

Our Chargers vs Chiefs best bets are based on market-leading modelling and wagering expertise to give you the best possible advice every day of the year.

While the Chiefs have a higher chance of winning the game, betting on the Chargers to win is our preferred option because of the edge found when comparing our data-led probabilities to the odds currently available.

Making use of the edges seen on Stats Insider is one of the keys to achieving long-term success as a bettor.

Chargers vs Chiefs: Prediction

Stats Insider's predicted final score for Chargers vs Chiefs at Corinthians Arena in Week 1 is the Chiefs winning 23-21.

This prediction is based on each team's average score following 10,000 game simulations.

Stats Insider provides full coverage of the LA Chargers vs Kansas City game in Week 1, including data-driven predictions and the best betting tips.

Remember, our model updates regularly, so refresh this page for the latest betting tips before the LA Chargers vs Kansas City game.

As always, see our Best Bets for the best tips for every NFL game, plus predictions for a wide range of other sports.

Chargers vs Chiefs: Week 1 Essential Details

The NFL Week 1 match-up between the Chargers and Chiefs at Corinthians Arena is scheduled to commence at 10:00am AEST on Saturday, September 6.

• Teams: Los Angeles Chargers vs Kansas City Chiefs
• Date: Saturday 6 September 2025
• Time: 10:00am AEST
• Venue: Corinthians Arena

All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.

Conclusion

Our LA Chargers vs Kansas City predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.

If you choose to use our predictions for betting purposes, it's crucial to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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