Chargers vs Cardinals Prediction and Preview - NFL Week 1, 2026
Last updated: Sep 13, 2026, 8:25PM | Published: Aug 30, 2026, 8:26PM
The Los Angeles Chargers will sqaure off with the Arizona Cardinals in NFL Week 1 action at SoFi Stadium on Monday, starting at 6:25am AEST.
This article features Stats Insider's prediction and tips for the Chargers vs Cardinals game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising advanced computer power and data, Stats Insider has simulated the result of Monday's LA Chargers vs Arizona NFL match-up 10,000 times.
Our proven predictive analytics model currently gives the Chargers a 77% chance of defeating the Cardinals in Week 1 of the NFL season.
Chargers vs Cardinals: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at SoFi Stadium are shown below:
- Head to Head: Chargers $1.20, Cardinals $4.75
- Line: Chargers -9.5 ($1.91), Cardinals +9.5 ($1.91)
- Total (Over/Under 46.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Chargers at $1.20 and the Cardinals at $4.75.
The Chargers are listed as 9.5-point favourites against the Cardinals, with odds of $1.91 available at Bet365.
For the underdog Cardinals (+9.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 46.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the bookmakers have got it right and both the Chargers and the Cardinals have a 50% chance of covering the line.
The 46.5-point over/under is expected to stay under 51% of the time.
Chargers vs Cardinals: Betting Tips
- Head to Head: Arizona at $4.75 with Bet365
- Line: Cardinals +9.5 at $1.91 with Bet365
- Total Points: Under 46.5 at $1.91 with Bet365
These Chargers vs Cardinals predictions are based on market-leading modelling and gambling expertise to provide you with the best possible advice 24/7.
While the Chargers have a higher chance of winning the game, betting on the Cardinals to win is our preferred option because of the 1.7% edge found when comparing our data-driven probabilities to the odds currently available.
Taking advantage of the edges seen here at Stats Insider is one of the keys to achieving long-term success as a bettor.
Chargers vs Cardinals: Prediction
Stats Insider's predicted final score for Chargers vs Cardinals at SoFi Stadium in Week 1 is the Chargers winning 27-18.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the LA Chargers vs Arizona game in Week 1, including data-driven predictions and live updatestips.
18+. Odds correct at time of publishing and subject to change.Chargers vs Cardinals: TD Scorer Tips
Who will score an anytime touchdown in Chargers vs Cardinals? The latest data is in.
According to Stats Insider, Los Angeles' Omarion Hampton is the most likely player to score the first touchdown in Chargers vs Cardinals.
Hampton has a 13.1% chance of getting in for six first at SoFi Stadium, while the Chargers RB has a 49.3% chance of reaching the end zone at any point in the game.
Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Chargers First TD Tips
- Omarion Hampton: 13.1% probability
- Quentin Johnston: 8.1% probability
- Ladd McConkey: 7.8% probability
- Keaton Mitchell: 4.2% probability
- Tre' Harris: 3.7% probability
Cardinals First TD Tips
- Jeremiyah Love: 8.0% probability
- Tyler Allgeier: 6.7% probability
- Trey McBride: 6.2% probability
- Marvin Harrison: 5.4% probability
- Michael Wilson: 4.8% probability
Anytime Touchdown Scorer Tips
Chargers Anytime TD Tips
- Omarion Hampton: 49.3% probability
- Quentin Johnston: 34.4% probability
- Ladd McConkey: 33.3% probability
- Keaton Mitchell: 19.7% probability
- Tre' Harris: 17.4% probability
Cardinals Anytime TD Tips
- Jeremiyah Love: 33.5% probability
- Tyler Allgeier: 29.1% probability
- Trey McBride: 27.3% probability
- Marvin Harrison: 23.9% probability
- Michael Wilson: 21.7% probability
Chargers-Cardinals Projected Player Stats
Of the starting quarterbacks, the Chargers' Justin Herbert is projected for 240 passing yards, while the Cardinals' Jacoby Brissett is expected to throw for 233 yards.
Chargers Starting QB
- Justin Herbert: 240 projected passing yards
Cardinals Starting QB
- Jacoby Brissett: 233 projected passing yards
Chargers Rushing Yards
- Omarion Hampton: 73 projected yards
- Keaton Mitchell: 28 projected yards
- Justin Herbert: 24 projected yards
Cardinals Rushing Yards
- Jeremiyah Love: 39 projected yards
- Tyler Allgeier: 38 projected yards
- Jacoby Brissett: 13 projected yards
Chargers Receiving Yards
- Ladd McConkey: 63 projected yards
- Quentin Johnston: 48 projected yards
- Tre' Harris: 33 projected yards
- Charlie Kolar: 23 projected yards
- Oronde Gadsden: 18 projected yards
Cardinals Receiving Yards
- Trey McBride: 59 projected yards
- Marvin Harrison: 52 projected yards
- Michael Wilson: 48 projected yards
- Kendrick Bourne: 26 projected yards
- Jeremiyah Love: 19 projected yards
Our model updates frequently, so bookmark this page for the latest betting predictions before the LA Chargers vs Arizona match-up.
As always, see Stats Insider's Best Bets to get betting tips on every NFL game, as well as predictions for a wide range of other sports.
Chargers vs Cardinals: Week 1 Essential Details
The NFL Week 1 match-up between the Chargers and Cardinals at SoFi Stadium is scheduled to begin at 6:25am AEST on Monday.
- Teams: Los Angeles Chargers vs Arizona Cardinals
- Date: Monday 14 September 2026
- Time: 6:25am AEST
- Venue: SoFi Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our LA Chargers vs Arizona predictions have been made based on 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's important to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on NFL
Stats Insider is your home for betting on the NFL in Australia, with the latest NFL betting news, predictions for every NFL game, and Super Bowl odds for the NFL.
