Chargers vs Cardinals Prediction and Preview - NFL Week 1, 2026

The Los Angeles Chargers will take on the Arizona Cardinals in NFL Week 1 action at SoFi Stadium on Monday, September 14, beginning at 6:25am AEST.

This article features Stats Insider's free betting tips for the Chargers vs Cardinals game, as well as the latest betting odds in Australia.

Who Will Win?

Using trusted machine learning and data, Stats Insider has simulated the outcome of Cardinals vs Chargers 10,000 times.

Our leading predictive analytics model gives the Chargers an 84% chance of winning against the Cardinals at SoFi Stadium.

Chargers vs Cardinals: Odds

The latest Bet365 betting odds in Australia for this NFL game at SoFi Stadium are listed here:

• Head to Head: Chargers $1.17, Cardinals $5.25
• Line: Chargers -10.5 ($1.91), Cardinals +10.5 ($1.91)
• Total (Over/Under 47.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Chargers at $1.17 and the Cardinals at $5.25.

The Chargers are listed as 10.5-point favourites against the Cardinals, with odds of $1.91 available at Bet365.

For the underdog Cardinals (+10.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 47.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's model, the Cardinals (+10.5) are predicted to cover the line 52% of the time, while the 47.5-point over/under is expected to stay under 60% of the time.

Chargers vs Cardinals: Best Bets

• Head to Head: LA Chargers at $1.17 with Bet365
• Line: Cardinals +10.5 at $1.91 with Bet365
• Total Points: Under 47.5 at $1.91 with Bet365

When you see a 🔥, that means you've found one of Stats Insider's best tips of the day across any sport.

Our Chargers vs Cardinals predictions are based on complex modelling and wagering intelligence to help you place smarter bets with your chosen online bookie.

Chargers vs Cardinals: Prediction

Stats Insider's predicted final score for Chargers vs Cardinals at SoFi Stadium in Week 1 is the Chargers winning 27-17.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full betting coverage of the LA Chargers vs Arizona game in Week 1, including data-driven predictions and free betting tips.

Remember, our model updates regularly, so keep checking this article for the latest betting predictions before the LA Chargers vs Arizona match-up.

As always, see Stats Insider's Best Bets to get betting tips on every NFL game, plus predictions for a wide range of other sports.

Chargers vs Cardinals: Week 1 Essential Details

The NFL Week 1 game between the Chargers and Cardinals at SoFi Stadium is scheduled to commence at 6:25am AEST on Monday, September 14.

• Teams: Los Angeles Chargers vs Arizona Cardinals
• Date: Monday 14 September 2026
• Time: 6:25am AEST
• Venue: SoFi Stadium

All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.

Conclusion

Our LA Chargers vs Arizona predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.

If you choose to use our predictions for betting purposes, it's crucial that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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