Chargers vs Broncos Prediction and Preview - NFL Week 3, 2025

The Los Angeles Chargers will face the Denver Broncos in NFL Week 3 action at SoFi Stadium on Monday, starting at 6:05am AEST.

This article features Stats Insider's top betting tips for the Chargers vs Broncos game, plus the latest betting odds in Australia.

Who Will Win?

Utilising advanced machine learning and data, Stats Insider has simulated the outcome of Monday's LA Chargers vs Denver NFL game 10,000 times.

Our leading predictive analytics model currently gives the Chargers a 55% chance of winning against the Broncos at SoFi Stadium.

Chargers vs Broncos: Odds

The current Bet365 betting odds in Australia for Monday's NFL game at SoFi Stadium are shown below:

• Head to Head: Chargers $1.71, Broncos $2.20
• Line: Chargers -2.5 ($1.91), Broncos +2.5 ($1.91)
• Total (Over/Under 45.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Chargers at $1.71 and the Broncos at $2.20.

The Chargers are listed as 2.5-point favourites against the Broncos, with odds of $1.91 available at Bet365.

For the underdog Broncos (+2.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 45.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the Broncos (+2.5) are predicted to cover the line 54% of the time, while the 45.5-point over/under is expected to stay under 53% of the time.

Chargers vs Broncos: Best Bets

• Head to Head: Denver at $2.20 with Bet365
• Line: Broncos +2.5 at $1.91 with Bet365
• Total Points: Under 45.5 at $1.91 with Bet365

These Chargers vs Broncos betting tips are based on world-class modelling and wagering intelligence to help you place smarter bets with your chosen online bookie.

While the Chargers have a higher chance of winning the game, betting on the Broncos to win is our recommended option because of the edge identified when comparing our data-driven probabilities to the odds currently on offer.

Making use of the edges seen here at Stats Insider is crucial to being a profitable punter in the long run.

Chargers vs Broncos: Prediction

Stats Insider's predicted final score for Chargers vs Broncos at SoFi Stadium in Week 3 is the Chargers winning 23-21.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full betting coverage of the LA Chargers vs Denver game in Week 3, including data-driven predictions and free betting tips.

Our model updates regularly, so bookmark this article for the latest betting predictions before the LA Chargers vs Denver match-up.

As always, see Stats Insider's Best Bets for the best tips for every NFL game, plus predictions for a wide range of other sports.

Chargers vs Broncos: Week 3 Essential Details

The NFL Week 3 match-up between the Chargers and Broncos at SoFi Stadium is scheduled to start at 6:05am AEST on Monday.

• Teams: Los Angeles Chargers vs Denver Broncos
• Date: Monday 22 September 2025
• Time: 6:05am AEST
• Venue: SoFi Stadium

All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.

Conclusion

Our LA Chargers vs Denver predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.

If you decide to use our NFL predictions for betting purposes, it's important to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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