Cardinals vs Seahawks Prediction and Preview - NFL Week 4, 2025
Last updated: Sep 26, 2025, 12:12AM | Published: Sep 19, 2025, 4:03AM
The Arizona Cardinals will take on the Seattle Seahawks in NFL Week 4 action at State Farm Stadium on Friday, starting at 10:15am AEST.
This article features Stats Insider's best betting tips for the Cardinals vs Seahawks game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on advanced computer power and data, Stats Insider has simulated the outcome of Friday's Arizona vs Seattle NFL game 10,000 times.
Our proven predictive analytics model gives the Seahawks a 58% chance of winning against the Cardinals in Week 4 of the NFL season.
Cardinals vs Seahawks: Odds
The latest Bet365 betting odds in Australia for Friday's NFL game at State Farm Stadium are shown here:
- Head to Head: Cardinals $2.00, Seahawks $1.83
- Line: Cardinals +1 ($1.91), Seahawks -1 ($1.91)
- Total (Over/Under 43.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Cardinals at $2.00 and the Seahawks at $1.83.
The Cardinals are listed as 1-point underdogs against the Seahawks, with odds of $1.91 available at Bet365.
For the favourite Seahawks (-1) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 43.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Seahawks (-1) are predicted to cover the line 52% of the time, while the 43.5-point over/under is expected to stay under 54% of the time.
Cardinals vs Seahawks: Betting Tips
- Head to Head: Seattle at $1.83 with Bet365
- Line: Seahawks -1 at $1.91 with Bet365
- Total Points: Under 43.5 at $1.91 with Bet365
Our Cardinals vs Seahawks predictions are based on complex modelling and betting experience to help you place better bets with your chosen online bookie.
Cardinals vs Seahawks: Prediction
Stats Insider's predicted final score for Cardinals vs Seahawks at State Farm Stadium in Week 4 is the Seahawks winning 22-20.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the Arizona vs Seattle game in Week 4, including data-driven predictions and live win probabilitiestips.
18+. Odds correct at time of publishing and subject to change.Cardinals vs Seahawks: TD Scorer Tips
Who will score the first touchdown in Cardinals vs Seahawks? The latest data is in.
According to Stats Insider, Seattle's Kenneth Walker is the most likely player to score the first touchdown in Cardinals vs Seahawks.
Walker has an 11.5% chance of scoring the first TD at State Farm Stadium, while the Seahawks RB has a 46.3% chance of scoring an anytime touchdown.
Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Cardinals First TD Tips
- Trey Benson: 10.1% probability
- Marvin Harrison: 7.9% probability
- Trey McBride: 7.8% probability
- Kyler Murray: 5.4% probability
- Emari Demercado: 4.1% probability
Seahawks First TD Tips
- Kenneth Walker: 11.5% probability
- Jaxon Smith-Njigba: 8.4% probability
- Zach Charbonnet: 7.9% probability
- Cooper Kupp: 5.3% probability
- Tory Horton: 4.0% probability
Anytime Touchdown Scorer Tips
Cardinals Anytime TD Tips
- Trey Benson: 37.1% probability
- Marvin Harrison: 30.3% probability
- Trey McBride: 30.1% probability
- Kyler Murray: 22.1% probability
- Emari Demercado: 17.3% probability
Seahawks Anytime TD Tips
- Kenneth Walker: 46.3% probability
- Jaxon Smith-Njigba: 36.6% probability
- Zach Charbonnet: 34.7% probability
- Cooper Kupp: 25.1% probability
- Tory Horton: 19.6% probability
Cardinals-Seahawks Projected Player Stats
Of the starting quarterbacks, the Cardinals' Kyler Murray is projected for 228 passing yards, while the Seahawks' Sam Darnold is expected to throw for 231 yards.
Cardinals Starting QB
- Kyler Murray: 228 projected passing yards
Seahawks Starting QB
- Sam Darnold: 231 projected passing yards
Cardinals Rushing Yards
- Trey Benson: 60 projected yards
- Kyler Murray: 33 projected yards
- Emari Demercado: 18 projected yards
Seahawks Rushing Yards
- Kenneth Walker: 54 projected yards
- Zach Charbonnet: 42 projected yards
- Sam Darnold: 10 projected yards
Cardinals Receiving Yards
- Trey McBride: 64 projected yards
- Marvin Harrison: 55 projected yards
- Michael Wilson: 30 projected yards
- Trey Benson: 23 projected yards
- Greg Dortch: 22 projected yards
Seahawks Receiving Yards
- Jaxon Smith-Njigba: 88 projected yards
- Cooper Kupp: 47 projected yards
- Tory Horton: 31 projected yards
- AJ Barner: 20 projected yards
- Kenneth Walker: 15 projected yards
Remember, our model updates regularly, so refresh this page for the latest betting predictions before the Arizona vs Seattle match-up.
As always, see Stats Insider's Best Bets to get betting tips for every NFL game, as well as predictions for a wide range of other sports.
Cardinals vs Seahawks: Week 4 Essential Details
The NFL Week 4 game between the Cardinals and Seahawks at State Farm Stadium is scheduled to commence at 10:15am AEST on Friday.
- Teams: Arizona Cardinals vs Seattle Seahawks
- Date: Friday 26 September 2025
- Time: 10:15am AEST
- Venue: State Farm Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Arizona vs Seattle predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you decide to use our NFL predictions for betting purposes, it's vital to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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