Cardinals vs Seahawks Prediction and Preview - NFL Week 4, 2025

The Arizona Cardinals will take on the Seattle Seahawks in NFL Week 4 action at State Farm Stadium on Friday, September 26, commencing at 10:15am AEST.

This article features Stats Insider's top betting tips for the Cardinals vs Seahawks game, as well as the latest betting odds in Australia.

Who Will Win?

Utilising trusted computer power and data, Stats Insider has simulated the outcome of Seahawks vs Cardinals 10,000 times.

Our independent predictive analytics model currently gives the Cardinals a 59% chance of defeating the Seahawks at State Farm Stadium.

Cardinals vs Seahawks: Odds

The current Bet365 betting odds in Australia for this NFL game at State Farm Stadium are listed here:

• Head to Head: Cardinals $1.74, Seahawks $2.15
• Line: Cardinals -2.5 ($1.91), Seahawks +2.5 ($1.91)
• Total (Over/Under 44 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Cardinals at $1.74 and the Seahawks at $2.15.

The Cardinals are 2.5-point favourites against the Seahawks, with odds of $1.91 available at Bet365.

For the underdog Seahawks (+2.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 44 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's model, the bookmakers have got it right and both the Cardinals and the Seahawks have a 50% chance of covering the line.

The 44-point over/under is expected to go over 53% of the time.

Cardinals vs Seahawks: Best Bets

• Head to Head: Arizona at $1.74 with Bet365
• Line: Seahawks +2.5 at $1.91 with Bet365
• Total Points: Over 44 at $1.91 with Bet365

These Cardinals vs Seahawks predictions are based on complex modelling and betting expertise to bring you the best possible advice around the clock.

Cardinals vs Seahawks: Prediction

Stats Insider's predicted final score for Cardinals vs Seahawks at State Farm Stadium in Week 4 is the Cardinals prevailing 24-21.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full coverage of the Arizona vs Seattle game in Week 4, including data-driven predictions and expert tips.

Remember, our model updates frequently, so refresh this page for the latest betting tips before the Arizona vs Seattle match-up.

As always, see Stats Insider's Best Bets to get the best tips for every NFL game, plus predictions for a wide range of other sports.

Cardinals vs Seahawks: Week 4 Essential Details

The NFL Week 4 match-up between the Cardinals and Seahawks at State Farm Stadium is scheduled to commence at 10:15am AEST on Friday, September 26.

• Teams: Arizona Cardinals vs Seattle Seahawks
• Date: Friday 26 September 2025
• Time: 10:15am AEST
• Venue: State Farm Stadium

All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.

Conclusion

Our Arizona vs Seattle predictions are based on 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.

If you decide to use our NFL predictions for betting purposes, it's vital that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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