Cardinals vs Seahawks Prediction and Preview - NFL Week 2, 2026
Last updated: Sep 20, 2026, 8:26PM | Published: Sep 13, 2026, 4:08AM
The Arizona Cardinals will face the favoured Seattle Seahawks in NFL Week 2 action at State Farm Stadium on Monday, starting at 6:25am AEST.
This article features Stats Insider's prediction and tips for the Cardinals vs Seahawks game, plus the latest betting odds and touchdown scorer tips.
Who Will Win?
Using trusted machine learning and data, Stats Insider has simulated the outcome of Monday's Arizona vs Seattle NFL game 10,000 times.
Our proven predictive analytics model gives the Seahawks a 61% chance of defeating the Cardinals in Week 2 of the NFL season.
Cardinals vs Seahawks: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at State Farm Stadium are shown here:
- Head to Head: Cardinals $2.75, Seahawks $1.48
- Line: Cardinals +3.5 ($1.91), Seahawks -3.5 ($1.91)
- Total (Over/Under 41.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Cardinals at $2.75 and the Seahawks at $1.48.
The Cardinals are 3.5-point underdogs against the Seahawks, with odds of $1.91 available at Bet365.
For the favourite Seahawks (-3.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 41.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+3.5) are predicted to cover the line 53% of the time, while the 41.5-point over/under is expected to go over 51% of the time.
Cardinals vs Seahawks: Betting Tips
- Head to Head: Arizona at $2.75 with Bet365
- Line: Cardinals +3.5 at $1.91 with Bet365
- Total Points: Over 41.5 at $1.91 with Bet365
Stats Insider's Cardinals vs Seahawks betting tips are based on market-leading modelling and wagering expertise to help you place smarter bets with your chosen online bookie.
While the Seahawks have a higher chance of winning the game, betting on the Cardinals to win is our preferred option because of the 2.4% edge identified when comparing our data-driven probabilities to the odds currently available.
Taking advantage of the edges published on Stats Insider is pivotal to being profitable in the long run.
Cardinals vs Seahawks: Prediction
Stats Insider's predicted final score for Cardinals vs Seahawks at State Farm Stadium in Week 2 is the Seahawks winning 22-19.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the Arizona vs Seattle game in Week 2, including data-driven predictions and live scorestips.
18+. Odds correct at time of publishing and subject to change.Cardinals vs Seahawks: TD Scorer Tips
Who will score the first touchdown in Cardinals vs Seahawks? The latest data is in.
According to Stats Insider, Arizona's Jeremiyah Love is the most likely player to score the first touchdown in Cardinals vs Seahawks.
Love has a 9.8% chance of getting in for six first at State Farm Stadium, while the Cardinals RB has a 32.9% chance of registering an anytime touchdown.
Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Cardinals First TD Tips
- Jeremiyah Love: 9.8% probability
- Trey McBride: 8.0% probability
- Tyler Allgeier: 7.2% probability
- Marvin Harrison: 5.6% probability
- Michael Wilson: 5.3% probability
Seahawks First TD Tips
- Jaxon Smith-Njigba: 9.5% probability
- Jadarian Price: 9.0% probability
- George Holani: 7.0% probability
- AJ Barner: 5.0% probability
- Rashid Shaheed: 4.0% probability
Anytime Touchdown Scorer Tips
Cardinals Anytime TD Tips
- Jeremiyah Love: 32.9% probability
- Trey McBride: 27.7% probability
- Tyler Allgeier: 25.6% probability
- Marvin Harrison: 20.3% probability
- Michael Wilson: 19.6% probability
Seahawks Anytime TD Tips
- Jaxon Smith-Njigba: 37.3% probability
- Jadarian Price: 35.8% probability
- George Holani: 29.1% probability
- AJ Barner: 21.9% probability
- Rashid Shaheed: 18.0% probability
Cardinals-Seahawks Projected Player Stats
Of the starting quarterbacks, the Cardinals' Jacoby Brissett is projected for 223 passing yards, while the Seahawks' Drew Lock is expected to throw for 205 yards.
Cardinals Starting QB
- Jacoby Brissett: 223 projected passing yards
Seahawks Starting QB
- Drew Lock: 205 projected passing yards
Cardinals Rushing Yards
- Jeremiyah Love: 42 projected yards
- Tyler Allgeier: 36 projected yards
- Jacoby Brissett: 13 projected yards
Seahawks Rushing Yards
- Jadarian Price: 66 projected yards
- George Holani: 31 projected yards
- Drew Lock: 13 projected yards
Cardinals Receiving Yards
- Trey McBride: 62 projected yards
- Michael Wilson: 44 projected yards
- Marvin Harrison: 42 projected yards
- Kendrick Bourne: 31 projected yards
- Jeremiyah Love: 20 projected yards
Seahawks Receiving Yards
- Jaxon Smith-Njigba: 84 projected yards
- Rashid Shaheed: 30 projected yards
- Cooper Kupp: 29 projected yards
- AJ Barner: 27 projected yards
- Elijah Arroyo: 15 projected yards
Remember, our model updates frequently, so keep checking this page for the latest betting analysis before the Arizona vs Seattle game.
As always, see Stats Insider's Best Bets for betting tips for every NFL game, plus predictions for a wide range of other sports.
Cardinals vs Seahawks: Week 2 Essential Details
The NFL Week 2 match-up between the Cardinals and Seahawks at State Farm Stadium is scheduled to commence at 6:25am AEST on Monday.
- Teams: Arizona Cardinals vs Seattle Seahawks
- Date: Monday 21 September 2026
- Time: 6:25am AEST
- Venue: State Farm Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Arizona vs Seattle predictions are based on 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our NFL predictions for betting purposes, it's crucial that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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