Cardinals vs Seahawks Prediction and Preview - NFL Week 2, 2026
Last updated: Sep 13, 2026, 9:47AM | Published: Sep 13, 2026, 4:08AM
The Arizona Cardinals will sqaure off with the favoured Seattle Seahawks in NFL Week 2 action at State Farm Stadium on Monday, September 21, beginning at 6:25am AEST.
This article features Stats Insider's top betting tips for the Cardinals vs Seahawks game, along with the latest betting odds in Australia.
Who Will Win?
Based on trusted machine learning and data, Stats Insider has simulated the result of Seahawks vs Cardinals 10,000 times.
Our independent predictive analytics model gives the Seahawks a 79% chance of defeating the Cardinals in Week 2 of the NFL season.
Cardinals vs Seahawks: Odds
The current Bet365 betting odds in Australia for this NFL game at State Farm Stadium are listed below:
- Head to Head: Cardinals $4.90, Seahawks $1.19
- Line: Cardinals +9.5 ($1.91), Seahawks -9.5 ($1.91)
- Total (Over/Under 44.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Cardinals at $4.90 and the Seahawks at $1.19.
The Cardinals are 9.5-point underdogs against the Seahawks, with odds of $1.91 available at Bet365.
For the favourite Seahawks (-9.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 44.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Seahawks (-9.5) are predicted to cover the line 52% of the time, while the 44.5-point over/under is expected to go over 51% of the time.
Cardinals vs Seahawks: Best Bets
- Head to Head: Arizona at $4.90 with Bet365
- Line: Seahawks -9.5 at $1.91 with Bet365
- Total Points: Over 44.5 at $1.91 with Bet365
Today's Cardinals vs Seahawks betting tips are based on detailed simulations and wagering expertise to bring you the best possible advice every time.
While the Seahawks have a higher chance of winning the game, betting on the Cardinals to win is our preferred option due to the edge identified when comparing our data-led probabilities to the odds currently available.
Making use of the edges seen on Stats Insider is one of the keys to being a profitable punter in the long run.
Cardinals vs Seahawks: Prediction
Stats Insider's predicted final score for Cardinals vs Seahawks at State Farm Stadium in Week 2 is the Seahawks prevailing 27-17.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the Arizona vs Seattle game in Week 2, including data-driven predictions and expert tips.
18+. Odds correct at time of publishing and subject to change.Remember, our model updates regularly, so bookmark this article for the latest betting tips before the Arizona vs Seattle game.
As always, see Stats Insider's Best Bets for betting tips on every NFL game, as well as predictions for a wide range of other sports.
Cardinals vs Seahawks: Week 2 Essential Details
The NFL Week 2 game between the Cardinals and Seahawks at State Farm Stadium is scheduled to begin at 6:25am AEST on Monday, September 21.
- Teams: Arizona Cardinals vs Seattle Seahawks
- Date: Monday 21 September 2026
- Time: 6:25am AEST
- Venue: State Farm Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Arizona vs Seattle predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.
If you decide to use our NFL predictions for betting purposes, it's crucial that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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