Cardinals vs Royals Prediction and MLB Tips - 4 June 2025
Last updated: Jun 3, 2025, 11:45PM | Published: Jun 3, 2025, 5:33AM
The St. Louis Cardinals will sqaure off with the Kansas City Royals in MLB action at Busch Stadium on Wednesday, beginning at 9:45am AEST.
The Cardinals will have Andre Pallante (4-3, 4.23 ERA) start, up against Michael Lorenzen (3-6, 4.33 ERA) for the Royals.
This article features Stats Insider's prediction and tips for the Cardinals vs Royals game, plus the latest betting odds in Australia.
Who Will Win?
Using trusted computer power and data, Stats Insider has simulated the result of Wednesday's St. Louis vs Kansas City MLB match-up 10,000 times.
Our independent predictive analytics model currently gives the Cardinals a 57% chance of winning against the Royals at Busch Stadium.
Cardinals vs Royals: Odds
The current betting odds in Australia for Wednesday's MLB game at Busch Stadium are shown below:
- Head to Head: Cardinals $1.65, Royals $2.30
- Line: Cardinals -1.5 ($2.35), Royals +1.5 ($1.62)
- Total (Over/Under 9 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $1.65 and the Royals at $2.30.
The Cardinals are listed as 1.5-run favourites against the Royals, with odds of $2.35 available at TAB.
For the underdog Royals (+1.5) to cover the line, TAB offers odds of $1.62.
The over/under for total runs scored is set at 9 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Royals (+1.5) are predicted to cover the line 62% of the time, while the 9-run over/under is expected to stay under 56% of the time.
Cardinals vs Royals: Betting Tips
- Head to Head: Kansas City at $2.30 with TAB
- Line: Royals +1.5 at $1.62 with TAB
- Total Runs: Under 9 at $1.91 with TAB
Stats Insider's Cardinals vs Royals best bets are based on world-class simulations and wagering experience to help you place smarter bets with your chosen online bookie.
While the Cardinals have a higher chance of winning the game, betting on the Royals to win is our preferred option due to the 1.3% edge identified when comparing our data-led probabilities to the odds currently available.
Making use of the edges published on Stats Insider is crucial to achieving long-term profitability.
Cardinals vs Royals: Prediction
Stats Insider provides full coverage of the St. Louis vs Kansas City game on Wednesday, including data-driven predictions and computer tips.
Our model updates regularly, so refresh this article for the latest betting tips before the St. Louis vs Kansas City game.
As always, see Stats Insider's Best Bets for the best tips on every MLB game, plus predictions for a wide range of other sports.
Cardinals vs Royals: Essential Details
The game between the Cardinals and Royals at Busch Stadium is scheduled to commence at 9:45am AEST on Wednesday.
- Teams: St. Louis Cardinals vs Kansas City Royals
- Date: Wednesday 4 June 2025
- Time: 9:45am AEST
- Venue: Busch Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our St. Louis vs Kansas City predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's vital to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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