Cardinals vs Reds Prediction and MLB Tips - 17 September 2025
Last updated: Sep 16, 2025, 11:47PM | Published: Sep 15, 2025, 8:32PM
The St. Louis Cardinals will face the Cincinnati Reds in MLB action at Busch Stadium on Wednesday, commencing at 9:45am AEST.
The Cardinals will have Michael McGreevy (6-3, 4.44 ERA) start, while the Reds will counter with Andrew Abbott (9-6, 2.79 ERA).
This article features Stats Insider's prediction and tips for the Cardinals vs Reds game, plus the latest betting odds in Australia.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the result of Wednesday's St. Louis vs Cincinnati MLB game 10,000 times.
Our independent predictive analytics model gives the Reds a 52% chance of defeating the Cardinals at Busch Stadium.
Cardinals vs Reds: Odds
The latest betting odds in Australia for Wednesday's MLB game at Busch Stadium are listed below:
- Head to Head: Cardinals $2.05, Reds $1.80
- Line: Cardinals +1.5 ($1.62), Reds -1.5 ($2.35)
- Total (Over/Under 8 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $2.05 and the Reds at $1.80.
The Cardinals are listed as 1.5-run underdogs against the Reds, with odds of $1.62 available at TAB.
For the favourite Reds (-1.5) to cover the line, TAB offers odds of $2.35.
The over/under for total runs scored is set at 8 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 61% of the time, while the 8-run over/under is expected to is considered an equal 50-50 chance of hitting.
Cardinals vs Reds: Betting Tips
- Head to Head: St. Louis at $2.05 with TAB
- Line: Cardinals +1.5 at $1.62 with TAB
- Total Runs: Over 8 at $1.91 with TAB
Stats Insider's Cardinals vs Reds betting tips are based on complex modelling and gambling intelligence to help you place smarter bets with your chosen online bookie.
While the Reds have a higher chance of winning the game, betting on the Cardinals to win is our recommended option because of the 1.2% edge found when comparing our data-driven probabilities to the odds currently on offer.
Taking advantage of the edges published on Stats Insider is crucial to achieving long-term profitability.
Cardinals vs Reds: Prediction
Stats Insider provides full betting coverage of the St. Louis vs Cincinnati game on Wednesday, including data-driven predictions and live win probabilitiestips.
Remember, our model updates regularly, so keep checking this page for the latest betting analysis before the St. Louis vs Cincinnati match-up.
As always, see Stats Insider's Best Bets for the best tips on every MLB game, as well as predictions for a wide range of other sports.
Cardinals vs Reds: Essential Details
The game between the Cardinals and Reds at Busch Stadium is scheduled to commence at 9:45am AEST on Wednesday.
- Teams: St. Louis Cardinals vs Cincinnati Reds
- Date: Wednesday 17 September 2025
- Time: 9:45am AEST
- Venue: Busch Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our St. Louis vs Cincinnati predictions are based on 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's vital that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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