Cardinals vs Reds Prediction and MLB Tips - 16 September 2025
Last updated: Sep 15, 2025, 6:36AM | Published: Sep 14, 2025, 7:29PM
The St. Louis Cardinals will take on the Cincinnati Reds in MLB action at Busch Stadium on Tuesday, beginning at 9:45am AEST.
The Cardinals will have Matthew Liberatore (7-12, 4.35 ERA) start, up against Zack Littell (9-8, 3.78 ERA) for the Reds.
This article features Stats Insider's prediction and tips for the Cardinals vs Reds game, plus the latest betting odds in Australia.
Who Will Win?
Using advanced machine learning and data, Stats Insider has simulated the outcome of Tuesday's St. Louis vs Cincinnati MLB match-up 10,000 times.
Our proven predictive analytics model gives the Cardinals a 55% chance of winning against the Reds at Busch Stadium.
Cardinals vs Reds: Odds
The latest betting odds in Australia for Tuesday's MLB game at Busch Stadium are shown below:
- Head to Head: Cardinals $1.80, Reds $2.05
- Line: Cardinals -1.5 ($2.65), Reds +1.5 ($1.50)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $1.80 and the Reds at $2.05.
The Cardinals are listed as 1.5-run favourites against the Reds, with odds of $2.65 available at TAB.
For the underdog Reds (+1.5) to cover the line, TAB offers odds of $1.50.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Reds (+1.5) are predicted to cover the line 64% of the time, while the 8.5-run over/under is expected to stay under 51% of the time.
Cardinals vs Reds: Best Bets
- Head to Head: St. Louis at $1.80 with TAB
- Line: Reds +1.5 at $1.50 with TAB
- Total Runs: Under 8.5 at $1.91 with TAB
Today's Cardinals vs Reds predictions are based on detailed modelling and wagering expertise to help you place more informed bets with your chosen online bookie.
Cardinals vs Reds: Prediction
Stats Insider provides full coverage of the St. Louis vs Cincinnati game on Tuesday, including data-driven predictions and top betting tips.
Our model updates frequently, so bookmark this page for the latest betting analysis before the St. Louis vs Cincinnati game.
As always, see Stats Insider's Best Bets for betting tips for every MLB game, as well as predictions for a wide range of other sports.
Cardinals vs Reds: Essential Details
The game between the Cardinals and Reds at Busch Stadium is scheduled to begin at 9:45am AEST on Tuesday.
- Teams: St. Louis Cardinals vs Cincinnati Reds
- Date: Tuesday 16 September 2025
- Time: 9:45am AEST
- Venue: Busch Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our St. Louis vs Cincinnati predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our MLB predictions for betting purposes, it's important that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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