Cardinals vs Reds Prediction and MLB Tips - 16 September 2025
Last updated: Sep 15, 2025, 11:46PM | Published: Sep 14, 2025, 7:29PM
The St. Louis Cardinals will take on the Cincinnati Reds in MLB action at Busch Stadium on Tuesday, starting at 9:45am AEST.
Matthew Liberatore (7-12, 4.35 ERA) will start for the Cardinals, pitting him against Zack Littell (9-8, 3.78 ERA) for the Reds.
This article features Stats Insider's prediction and tips for the Cardinals vs Reds game, plus the latest betting odds in Australia.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the outcome of Tuesday's St. Louis vs Cincinnati MLB game 10,000 times.
Our independent predictive analytics model gives the Cardinals a 53% chance of winning against the Reds at Busch Stadium.
Cardinals vs Reds: Odds
The latest betting odds in Australia for Tuesday's MLB game at Busch Stadium are listed here:
- Head to Head: Cardinals $1.87, Reds $1.95
- Line: Cardinals -1.5 ($2.79), Reds +1.5 ($1.46)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $1.87 and the Reds at $1.95.
The Cardinals are 1.5-run favourites against the Reds, with odds of $2.79 available at TAB.
For the underdog Reds (+1.5) to cover the line, TAB offers odds of $1.46.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Reds (+1.5) are predicted to cover the line 64% of the time, while the 8.5-run over/under is expected to go over 51% of the time.
Cardinals vs Reds: Best Bets
- Head to Head: St. Louis at $1.87 with TAB
- Line: Cardinals -1.5 at $2.79 with TAB
- Total Runs: Under 8.5 at $1.91 with TAB
Stats Insider's Cardinals vs Reds best bets are based on world-class modelling and gambling intelligence to give you the best possible advice around the clock.
Even though the Reds are more likely to cover the line, our best bet of Cardinals -1.5 is based on the chance of that happening, as projected by our predictive analytics model, and the best odds available.
Furthermore, despite the Over being more likely to hit in this game, Under 8.5 is our best bet because of the better odds ($1.91) that are available from TAB.
Cardinals vs Reds: Prediction
Stats Insider provides full coverage of the St. Louis vs Cincinnati game on Tuesday, including data-driven predictions and computer tips.
Remember, our model updates regularly, so refresh this article for the latest betting tips before the St. Louis vs Cincinnati match-up.
As always, see our Best Bets for betting tips for every MLB game, as well as predictions for a wide range of other sports.
Cardinals vs Reds: Essential Details
The match-up between the Cardinals and Reds at Busch Stadium is scheduled to begin at 9:45am AEST on Tuesday.
- Teams: St. Louis Cardinals vs Cincinnati Reds
- Date: Tuesday 16 September 2025
- Time: 9:45am AEST
- Venue: Busch Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our St. Louis vs Cincinnati predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's vital to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on MLB
Stats Insider is your home for betting on the MLB in Australia, with the latest MLB betting news, predictions for every MLB game, and futures odds for the MLB.
