Cardinals vs Pirates Prediction and MLB Tips - 28 August 2025
Last updated: Aug 27, 2025, 11:47PM | Published: Aug 27, 2025, 5:33AM
The St. Louis Cardinals will face the Pittsburgh Pirates in MLB action at Busch Stadium on Thursday, starting at 9:45am AEST.
Sonny Gray (12-6, 4.34 ERA) will start for the Cardinals, pitting him against Carmen Mlodzinski (3-7, 3.89 ERA) for the Pirates.
This article features Stats Insider's prediction and tips for the Cardinals vs Pirates game, as well as the latest betting odds in Australia.
Who Will Win?
Using advanced computer power and data, Stats Insider has simulated the outcome of Thursday's St. Louis vs Pittsburgh MLB match-up 10,000 times.
Our leading predictive analytics model currently gives the Cardinals a 61% chance of beating the Pirates at Busch Stadium.
Cardinals vs Pirates: Odds
The current betting odds in Australia for Thursday's MLB game at Busch Stadium are shown here:
- Head to Head: Cardinals $1.56, Pirates $2.50
- Line: Cardinals -1.5 ($2.25), Pirates +1.5 ($1.67)
- Total (Over/Under 7.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $1.56 and the Pirates at $2.50.
The Cardinals are listed as 1.5-run favourites against the Pirates, with odds of $2.25 available at TAB.
For the underdog Pirates (+1.5) to cover the line, TAB offers odds of $1.67.
The over/under for total runs scored is set at 7.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Pirates (+1.5) are predicted to cover the line 59% of the time, while the 7.5-run over/under is expected to stay under 53% of the time.
Cardinals vs Pirates: Betting Tips
- Head to Head: Pittsburgh at $2.50 with TAB
- Line: Pirates +1.5 at $1.67 with TAB
- Total Runs: Under 7.5 at $1.91 with TAB
These Cardinals vs Pirates best bets are based on detailed simulations and gambling intelligence to bring you the best possible advice around the clock.
While the Cardinals have a higher chance of winning the game, betting on the Pirates to win is our recommended option because of the edge identified when comparing our data-driven probabilities to the odds currently on offer.
Making use of the edges seen on Stats Insider is crucial to achieving long-term profitability.
Cardinals vs Pirates: Prediction
Stats Insider provides full betting coverage of the St. Louis vs Pittsburgh game on Thursday, including data-driven predictions and live win probabilitiestips.
Our model updates frequently, so keep checking this page for the latest betting analysis before the St. Louis vs Pittsburgh game.
As always, see our Best Bets for the best tips on every MLB game, plus predictions for a wide range of other sports.
Cardinals vs Pirates: Essential Details
The game between the Cardinals and Pirates at Busch Stadium is scheduled to begin at 9:45am AEST on Thursday.
- Teams: St. Louis Cardinals vs Pittsburgh Pirates
- Date: Thursday 28 August 2025
- Time: 9:45am AEST
- Venue: Busch Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our St. Louis vs Pittsburgh predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our MLB predictions for betting purposes, it's important that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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