Cardinals vs Pirates Prediction and MLB Tips - 27 August 2025
Last updated: Aug 26, 2025, 11:46PM | Published: Aug 25, 2025, 6:34PM
The St. Louis Cardinals will sqaure off with the Pittsburgh Pirates in MLB action at Busch Stadium on Wednesday, commencing at 9:45am AEST.
Andre Pallante (6-11, 5.17 ERA) will be on the bump for the Cardinals, up against Mitch Keller (5-12, 4.34 ERA) for the Pirates.
This article features Stats Insider's free betting tips for the Cardinals vs Pirates game, along with the latest betting odds in Australia.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the outcome of Wednesday's St. Louis vs Pittsburgh MLB match-up 10,000 times.
Our proven predictive analytics model currently gives the Cardinals a 54% chance of defeating the Pirates at Busch Stadium.
Cardinals vs Pirates: Odds
The current betting odds in Australia for Wednesday's MLB game at Busch Stadium are listed below:
- Head to Head: Cardinals $1.80, Pirates $2.05
- Line: Cardinals -1.5 ($2.63), Pirates +1.5 ($1.51)
- Total (Over/Under 8.056 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $1.80 and the Pirates at $2.05.
The Cardinals are listed as 1.5-run favourites against the Pirates, with odds of $2.63 available at TAB.
For the underdog Pirates (+1.5) to cover the line, TAB offers odds of $1.51.
The over/under for total runs scored is set at 8.056 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Pirates (+1.5) are predicted to cover the line 64% of the time, while the 8.056-run over/under is expected to is considered an equal 50-50 chance of hitting.
Cardinals vs Pirates: Betting Tips
- Head to Head: St. Louis at $1.80 with TAB
- Line: Pirates +1.5 at $1.51 with TAB
- Total Runs: Over 8.056 at $1.91 with TAB
These Cardinals vs Pirates best bets are based on detailed simulations and betting experience to bring you the best possible advice around the clock.
Cardinals vs Pirates: Prediction
Stats Insider provides full coverage of the St. Louis vs Pittsburgh game on Wednesday, including data-driven predictions and expert tips.
Our model updates frequently, so keep checking this page for the latest betting predictions before the St. Louis vs Pittsburgh match-up.
As always, see Stats Insider's Best Bets for the best tips for every MLB game, plus predictions for a wide range of other sports.
Cardinals vs Pirates: Essential Details
The match-up between the Cardinals and Pirates at Busch Stadium is scheduled to start at 9:45am AEST on Wednesday.
- Teams: St. Louis Cardinals vs Pittsburgh Pirates
- Date: Wednesday 27 August 2025
- Time: 9:45am AEST
- Venue: Busch Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our St. Louis vs Pittsburgh predictions are based on 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our MLB predictions for betting purposes, it's vital that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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