Cardinals vs Pirates Prediction and MLB Tips - 22 May 2026
Last updated: May 21, 2026, 5:15PM | Published: May 20, 2026, 5:30PM
The St. Louis Cardinals will face the Pittsburgh Pirates in MLB action at Busch Stadium on Friday, commencing at 3:15am AEST.
The Cardinals will send Dustin May (3-4, 4.81 ERA) to the mound, pitting him against Braxton Ashcraft (2-2, 3.09 ERA) for the Pirates.
This article features Stats Insider's prediction and tips for the Cardinals vs Pirates game, as well as the latest betting odds in Australia.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the outcome of Friday's St. Louis vs Pittsburgh MLB match-up 10,000 times.
Our independent predictive analytics model is currently unable to split the two teams, giving both the Cardinals and the Pirates an equal 50% chance of winning the game.
Cardinals vs Pirates: Odds
The current betting odds in Australia for Friday's MLB game at Busch Stadium are shown here:
- Head to Head: Cardinals $2.00, Pirates $1.83
- Line: Cardinals +1.5 ($1.61), Pirates -1.5 ($2.40)
- Total (Over/Under 7 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $2.00 and the Pirates at $1.83.
The Cardinals are 1.5-run underdogs against the Pirates, with odds of $1.61 available at TAB.
For the favourite Pirates (-1.5) to cover the line, TAB offers odds of $2.40.
The over/under for total runs scored is set at 7 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 62% of the time, while the 7-run over/under is expected to go over 57% of the time.
Cardinals vs Pirates: Best Bets
- Head to Head: St. Louis at $2.00 with TAB
- Line: Cardinals +1.5 at $1.61 with TAB
- Total Runs: Over 7 at $1.91 with TAB
Today's Cardinals vs Pirates predictions are based on complex modelling and betting expertise to help you place smarter bets with your chosen online bookie.
Cardinals vs Pirates: Prediction
Stats Insider provides full coverage of the St. Louis vs Pittsburgh game on Friday, including data-driven predictions and expert tips.
Our model updates frequently, so keep checking this page for the latest betting analysis before the St. Louis vs Pittsburgh match-up.
As always, see our Best Bets to get betting tips for every MLB game, plus predictions for a wide range of other sports.
Cardinals vs Pirates: Essential Details
The game between the Cardinals and Pirates at Busch Stadium is scheduled to commence at 3:15am AEST on Friday.
- Teams: St. Louis Cardinals vs Pittsburgh Pirates
- Date: Friday 22 May 2026
- Time: 3:15am AEST
- Venue: Busch Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our St. Louis vs Pittsburgh predictions have been made thanks to 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's vital to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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