Cardinals vs Pirates Prediction and MLB Tips - 20 May 2026
Last updated: May 19, 2026, 11:45PM | Published: May 18, 2026, 7:30PM
The St. Louis Cardinals will face the Pittsburgh Pirates in MLB action at Busch Stadium on Wednesday, commencing at 9:45am AEST.
The Cardinals will send Matthew Liberatore (2-2, 4.40 ERA) to the mound, up against Mitch Keller (4-2, 3.59 ERA) for the Pirates.
This article features Stats Insider's prediction and tips for the Cardinals vs Pirates game, along with the latest betting odds in Australia.
Who Will Win?
Using trusted computer power and data, Stats Insider has simulated the outcome of Wednesday's St. Louis vs Pittsburgh MLB match-up 10,000 times.
Our independent predictive analytics model gives the Cardinals a 52% chance of beating the Pirates at Busch Stadium.
Cardinals vs Pirates: Odds
The current betting odds in Australia for Wednesday's MLB game at Busch Stadium are listed below:
- Head to Head: Cardinals $1.87, Pirates $1.95
- Line: Cardinals -1.5 ($2.75), Pirates +1.5 ($1.48)
- Total (Over/Under 8 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $1.87 and the Pirates at $1.95.
The Cardinals are 1.5-run favourites against the Pirates, with odds of $2.75 available at TAB.
For the underdog Pirates (+1.5) to cover the line, TAB offers odds of $1.48.
The over/under for total runs scored is set at 8 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Pirates (+1.5) are predicted to cover the line 64% of the time, while the 8-run over/under is expected to go over 53% of the time.
Cardinals vs Pirates: Betting Tips
- Head to Head: St. Louis at $1.87 with TAB
- Line: Cardinals -1.5 at $2.75 with TAB
- Total Runs: Over 8 at $1.91 with TAB
Today's Cardinals vs Pirates predictions are based on market-leading simulations and wagering intelligence to provide you with the best possible advice 24/7/365.
Even though the Pirates are more likely to cover the line, our best bet of Cardinals -1.5 is based on the chance of that happening, as projected by our predictive analytics model, and the best odds available.
Cardinals vs Pirates: Prediction
Stats Insider provides full coverage of the St. Louis vs Pittsburgh game on Wednesday, including data-driven predictions and live win probabilitiestips.
Our model updates regularly, so keep checking this page for the latest betting analysis before the St. Louis vs Pittsburgh game.
As always, see our Best Bets to get the best tips on every MLB game, as well as predictions for a wide range of other sports.
Cardinals vs Pirates: Essential Details
The match-up between the Cardinals and Pirates at Busch Stadium is scheduled to commence at 9:45am AEST on Wednesday.
- Teams: St. Louis Cardinals vs Pittsburgh Pirates
- Date: Wednesday 20 May 2026
- Time: 9:45am AEST
- Venue: Busch Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our St. Louis vs Pittsburgh predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's important that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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