Cardinals vs Panthers Prediction and Preview - NFL Week 2, 2025
Last updated: Sep 14, 2025, 8:05PM | Published: Sep 7, 2025, 4:01AM
The Arizona Cardinals will sqaure off with the Carolina Panthers in NFL Week 2 action at State Farm Stadium on Monday, beginning at 6:05am AEST.
This article features Stats Insider's top betting tips for the Cardinals vs Panthers game, plus the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the result of Monday's Arizona vs Carolina NFL match-up 10,000 times.
Our independent predictive analytics model currently gives the Cardinals a 74% chance of defeating the Panthers at State Farm Stadium.
Cardinals vs Panthers: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at State Farm Stadium are shown below:
- Head to Head: Cardinals $1.30, Panthers $3.65
- Line: Cardinals -7 ($1.91), Panthers +7 ($1.91)
- Total (Over/Under 45.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Cardinals at $1.30 and the Panthers at $3.65.
The Cardinals are 7-point favourites against the Panthers, with odds of $1.91 available at Bet365.
For the underdog Panthers (+7) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 45.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Panthers (+7) are predicted to cover the line 54% of the time, while the 45.5-point over/under is expected to stay under 53% of the time.
Cardinals vs Panthers: Betting Tips
- Head to Head: Carolina at $3.65 with Bet365
- Line: Panthers +7 at $1.91 with Bet365
- Total Points: Under 45.5 at $1.91 with Bet365
Stats Insider's Cardinals vs Panthers predictions are based on world-class modelling and gambling intelligence to give you the best possible advice around the clock.
While the Cardinals have a higher chance of winning the game, betting on the Panthers to win is our preferred option because of the edge identified when comparing our data-driven probabilities to the odds currently on offer.
Taking advantage of the edges seen on Stats Insider is pivotal to being a profitable punter in the long run.
Cardinals vs Panthers: Prediction
Stats Insider's predicted final score for Cardinals vs Panthers at State Farm Stadium in Week 2 is the Cardinals winning 25-18.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the Arizona vs Carolina game in Week 2, including data-driven predictions and the best betting tips.
For in-depth analysis from US experts,, check out Dimers' detailed Cardinals vs Panthers prediction.
18+. Odds correct at time of publishing and subject to change.Cardinals vs Panthers: TD Scorer Tips
Who will score an anytime touchdown in Cardinals vs Panthers? The latest data is in.
According to Stats Insider, Arizona's James Conner is the most likely player to score the first touchdown in Cardinals vs Panthers.
Conner has a 15.6% chance of scoring the first TD at State Farm Stadium, while the Cardinals RB has a 51.5% chance of scoring an anytime touchdown.
Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Cardinals First TD Tips
- James Conner: 15.6% probability
- Marvin Harrison: 9.6% probability
- Trey McBride: 8.1% probability
- Kyler Murray: 6.1% probability
- Trey Benson: 4.8% probability
Panthers First TD Tips
- Chuba Hubbard: 11.9% probability
- Tetairoa McMillan: 6.5% probability
- Xavier Legette: 4.3% probability
- Ja'Tavion Sanders: 3.6% probability
- Bryce Young: 2.9% probability
Anytime Touchdown Scorer Tips
Cardinals Anytime TD Tips
- James Conner: 51.5% probability
- Marvin Harrison: 36.1% probability
- Trey McBride: 31.3% probability
- Kyler Murray: 24.5% probability
- Trey Benson: 19.9% probability
Panthers Anytime TD Tips
- Chuba Hubbard: 49.3% probability
- Tetairoa McMillan: 31.1% probability
- Xavier Legette: 21.9% probability
- Ja'Tavion Sanders: 18.6% probability
- Bryce Young: 15.5% probability
Cardinals-Panthers Projected Player Stats
Of the starting quarterbacks, the Cardinals' Kyler Murray is projected for 225 passing yards. The Panthers' Bryce Young is expected to throw for 213 yards.
Cardinals Starting QB
- Kyler Murray: 225 projected passing yards
Panthers Starting QB
- Bryce Young: 213 projected passing yards
Cardinals Rushing Yards
- James Conner: 72 projected yards
- Trey Benson: 39 projected yards
- Kyler Murray: 31 projected yards
Panthers Rushing Yards
- Chuba Hubbard: 67 projected yards
- Bryce Young: 20 projected yards
- Rico Dowdle: 19 projected yards
Cardinals Receiving Yards
- Trey McBride: 64 projected yards
- Marvin Harrison: 62 projected yards
- Michael Wilson: 31 projected yards
- James Conner: 19 projected yards
- Elijah Higgins: 12 projected yards
Panthers Receiving Yards
- Tetairoa McMillan: 65 projected yards
- Xavier Legette: 36 projected yards
- Hunter Renfrow: 30 projected yards
- Ja'Tavion Sanders: 26 projected yards
- Chuba Hubbard: 17 projected yards
Our model updates regularly, so keep checking this page for the latest betting tips before the Arizona vs Carolina game.
As always, see our Best Bets to get the best tips for every NFL game, as well as predictions for a wide range of other sports.
Cardinals vs Panthers: Week 2 Essential Details
The NFL Week 2 game between the Cardinals and Panthers at State Farm Stadium is scheduled to begin at 6:05am AEST on Monday.
- Teams: Arizona Cardinals vs Carolina Panthers
- Date: Monday 15 September 2025
- Time: 6:05am AEST
- Venue: State Farm Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Arizona vs Carolina predictions have been made thanks to 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.
If you choose to use our NFL predictions for betting purposes, it's vital that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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