Cardinals vs Padres Prediction and MLB Tips - 28 July 2025
Last updated: Jul 27, 2025, 6:15PM | Published: Jul 26, 2025, 8:38PM
The St. Louis Cardinals will sqaure off with the San Diego Padres in MLB action at Busch Stadium on Monday, starting at 4:15am AEST.
Michael McGreevy (2-1, 3.49 ERA) will get the ball for the Cardinals, up against Stephen Kolek (3-5, 4.28 ERA) for the Padres.
This article features Stats Insider's prediction and tips for the Cardinals vs Padres game, along with the latest betting odds in Australia.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the outcome of Monday's St. Louis vs San Diego MLB match-up 10,000 times.
Our leading predictive analytics model gives the Cardinals a 53% chance of winning against the Padres at Busch Stadium.
Cardinals vs Padres: Odds
The latest betting odds in Australia for Monday's MLB game at Busch Stadium are shown here:
- Head to Head: Cardinals $1.77, Padres $2.10
- Line: Cardinals -1.5 ($2.54), Padres +1.5 ($1.54)
- Total (Over/Under 9 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Cardinals at $1.77 and the Padres at $2.10.
The Cardinals are 1.5-run favourites against the Padres, with odds of $2.54 available at TAB.
For the underdog Padres (+1.5) to cover the line, TAB offers odds of $1.54.
The over/under for total runs scored is set at 9 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Padres (+1.5) are predicted to cover the line 63% of the time, while the 9-run over/under is expected to stay under 56% of the time.
Cardinals vs Padres: Betting Tips
- Head to Head: San Diego at $2.10 with TAB
- Line: Padres +1.5 at $1.54 with TAB
- Total Runs: Under 9 at $1.91 with TAB
Stats Insider's Cardinals vs Padres best bets are based on market-leading modelling and betting intelligence to provide you with the best possible advice every day of the year.
While the Cardinals have a higher chance of winning the game, betting on the Padres to win is our recommended option due to the edge found when comparing our data-led probabilities to the odds currently on offer.
Making use of the edges published here at Stats Insider is one of the keys to achieving long-term profitability.
Cardinals vs Padres: Prediction
Stats Insider provides full betting coverage of the St. Louis vs San Diego game on Monday, including data-driven predictions and expert tips.
Remember, our model updates frequently, so refresh this page for the latest betting tips before the St. Louis vs San Diego match-up.
As always, see our Best Bets for the best tips for every MLB game, plus predictions for a wide range of other sports.
Cardinals vs Padres: Essential Details
The match-up between the Cardinals and Padres at Busch Stadium is scheduled to start at 4:15am AEST on Monday.
- Teams: St. Louis Cardinals vs San Diego Padres
- Date: Monday 28 July 2025
- Time: 4:15am AEST
- Venue: Busch Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our St. Louis vs San Diego predictions are based on 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you choose to use our MLB predictions for betting purposes, it's important that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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